Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways

Phα1β is a neurotoxin purified from spider venom that acts as a high-voltage-activated (HVA) calcium channel blocker. This spider peptide has shown a high selectivity for N-type HVA calcium channels (NVACC) and an analgesic effect in several animal models of pain. Its activity was associated with a...

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Bibliographic Details

Published in:	The journal of venomous animals and toxins including tropical diseases Vol. 27
Main Authors:	Silva, Juliana Figueira da, Binda, Nancy Scardua, Pereira, Elizete Maria Rita, Lavor, Mário Sérgio Lima de, Vieira, Luciene Bruno, Souza, Alessandra Hubner de, Rigo, Flávia Karine, Ferrer, Hèlia Tenza, Castro Júnior, Célio José de, Ferreira, Juliano, Gomez, Marcus Vinicius
Format:	Journal Article
Language:	English
Published:	Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP 2021 Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) SciELO
Subjects:	Analgesia CTK 01512-2 Pain Phα1β peptide Review TOXICOLOGY TROPICAL MEDICINE TRPA1 Voltage-activated calcium channels Analgesia Pain Voltage-activated calcium channels Phα1β peptide CTK 01512-2 TRPA1
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