Classification of aberrant primary afferents in the substantia gelatinosa of the rat following neonatal capsaicin treatment

Administration of capsaicin to newborn rats results in a loss of a large percentage of primary afferent C fibers many of which terminate in the substantia gelatinosa (SG). Using the Golgi silver impregnation technique, the present study shows that the loss of C fibers results in an invasion of aberr...

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Bibliographic Details
Published in:	Neuroscience letters Vol. 74; no. 2; p. 139
Main Authors:	Beal, J A, Knight, D S
Format:	Journal Article
Language:	English
Published:	Ireland 24-02-1987
Subjects:	Animals Animals, Newborn Capsaicin - pharmacology Mechanoreceptors - pathology Nerve Fibers - drug effects Neuronal Plasticity Neurons, Afferent - drug effects Rats Spinal Cord - drug effects Substantia Gelatinosa - drug effects Substantia Gelatinosa - pathology
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Summary:	Administration of capsaicin to newborn rats results in a loss of a large percentage of primary afferent C fibers many of which terminate in the substantia gelatinosa (SG). Using the Golgi silver impregnation technique, the present study shows that the loss of C fibers results in an invasion of aberrant myelinated primary afferents in the SG by 10 days after birth. The aberrant afferents, identified on the basis of their distinctive collateral arborizations, are derived from hair follicles and slowly adapting type I mechanoreceptors.
ISSN:	0304-3940
DOI:	10.1016/0304-3940(87)90139-x