Stimulation of PAR-1 or PAR-4 promotes similar pattern of VEGF and endostatin release and pro-angiogenic responses mediated by human platelets

Background: Platelets mediate angiogenesis through the secretion of several factors, including the pro-angiogenic vascular endothelial growth factor (VEGF) and the anti-angiogenic endostatin. Although previous findings indicated that these molecules are packed into different alpha-granules and selec...

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Bibliographic Details
Published in:	Platelets (Edinburgh) Vol. 26; no. 8; pp. 799 - 804
Main Authors:	Etulain, J., Mena, H. A., Negrotto, S., Schattner, M.
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare 17-11-2015
Subjects:	Angiogenesis Blood Platelets - drug effects Blood Platelets - metabolism endostatin Endostatins - secretion Endothelial Cells - metabolism Humans Neovascularization, Physiologic Oligopeptides - pharmacology Platelet Activation - drug effects platelet alpha-granules protease-activated receptors Receptor, PAR-1 - agonists Receptors, Thrombin - agonists Vascular Endothelial Growth Factor A - metabolism VEGF protease-activated receptors Angiogenesis platelet alpha-granules endostatin VEGF
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