HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells

Agents that inhibit histone deacetylases (HDAC inhibitors) have been shown to enhance radiation response. The aim of this study was to evaluate the effects of low, minimally cytotoxic concentrations of the HDAC inhibitor, valproic acid (VPA), on radiation response of colorectal cancer cells. Cell li...

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Bibliographic Details
Published in:	Cancer biotherapy & radiopharmaceuticals Vol. 24; no. 6; p. 689
Main Authors:	Chen, Xufeng, Wong, Patty, Radany, Eric, Wong, Jeffrey Y C
Format:	Journal Article
Language:	English
Published:	United States 01-12-2009
Subjects:	Animals bcl-2-Associated X Protein - drug effects bcl-2-Associated X Protein - metabolism Cell Cycle - radiation effects Cell Division - drug effects Cell Division - radiation effects Cell Line, Tumor Colorectal Neoplasms - pathology Colorectal Neoplasms - radiotherapy Cytochromes c - metabolism Cytochromes c - radiation effects Flow Cytometry Genotype Histone Deacetylase Inhibitors - pharmacology Humans Membrane Potentials - radiation effects Mice Mitochondria - metabolism Mitochondria - radiation effects Mitochondrial Membranes - physiology Mitochondrial Membranes - radiation effects Radiation-Sensitizing Agents - pharmacology T-Lymphocytes - immunology T-Lymphocytes - radiation effects Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Valproic Acid - pharmacology
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