SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects

Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptiv...

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Bibliographic Details
Published in:	Acta biochimica et biophysica Sinica Vol. 54; no. 6; pp. 836 - 846
Main Authors:	Wang, Yating, Abolhassani, Hassan, Hammarström, Lennart, Pan-Hammarström, Qiang
Format:	Journal Article
Language:	English
Published:	China China Science Publishing & Media Ltd 01-06-2022
Subjects:	COVID-19 DNA Repair DNA repair mechanism Humans inborn errors of immunity Medicin och hälsovetenskap Pandemics - prevention & control primary immunodeficiency SARS-CoV-2 COVID-19 primary immunodeficiency inborn errors of immunity DNA repair mechanism
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Summary:	Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1672-9145 1745-7270 1745-7270
DOI:	10.3724/abbs.2022071