Alteration in circadian rhythm of plasma corticosterone in rats following sociopsychological stress induced by communication box

• Published in: Physiology & behavior Vol. 57; no. 1; pp. 41 - 47
• Main Authors: Ishikawa, Masahiro, Ohdo, Shigehiro, Watanabe, Hirokazu, Hara, Chiaka, Ogawa, Nobuya
• Format: Journal Article
• Language: English
• Published: Cambridge Elsevier Inc 1995; New York, NY Elsevier
• Subjects: Animals; Behavior, Animal - physiology; Behavioral psychophysiology; Biological and medical sciences; Body Weight; Circadian rhythm; Circadian Rhythm - physiology; Communication box; Corticosterone; Corticosterone - blood; Disease Models, Animal; Electroshock; Fundamental and applied biological sciences. Psychology; Hormones and behavior; Humans; Male; Mental Disorders - etiology; Psychological stress; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Wistar; Stress, Psychological - blood; Psychological stress; Rats; Circadian rhythm; Corticosterone; Communication box; Rat; Intraspecific relation; Rodentia; Male; Biological rhythm; Glucocorticoid; Stress; Blood plasma; Vertebrata; Visual stimulus; Mammalia; Social interaction; Animal; Adrenal hormone; Mental disorder
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/0031-9384(94)00192-8

The purpose of present study was to investigate the physiological characteristics of sociopsychological stress induced by the communication box method. In this method, the nonfoot shocked rats were used as the psychological stressed experimental group. The stress exposure was loaded for 1 h between 0900 and 1000, daily. The changes in circadian rhythm of plasma corticosterone were studied following the 3-day, 5-day, or 10-day stress exposure, respectively. Plasma corticosterone levels of foot shocked rats and nonfoot shocked rats following the 3-day or 5-day stress exposure were significantly higher than those of control rats. Particularly, the marked elevation of plasma corticosterone was observed at the peak time of circadian rhythm (2100) in the both stress groups. Consequently, the amplitude of 24 h rhythm increased significantly, but the acrophase was not changed. However, the changes of plasma corticosterone levels of both stress groups following the 10-day stress exposure approached those of control group. These results suggest that the repeated exposure of sociopsychological stress can influence the circadian rhythm of plasma corticosterone. The communication box method may be a valuable tool for researching the etiology of human psychiatric disorders with rhythm disturbance.