Sequence dependent hole evolution in DNA

Sequence dependent hole evolution in DNA

The paper examines thedynamical behavior of a radical cation(G(+*)) generated in adouble stranded DNA for differentoligonucleotide sequences. The resonancehole tunneling through an oligonucleotidesequence is studied by the method ofnumerical integration of self-consistentquantum-mechanical equations...

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Bibliographic Details
Published in:Journal of biological physics Vol. 30; no. 2; pp. 123 - 138
Main Author: Lakhno, V D
Format: Journal Article
Language:English
Published: Netherlands Springer Nature B.V 01-06-2004
Kluwer Academic Publishers
Subjects:
Biophysics
Deoxyribonucleic acid
DNA
Evolutionary biology
Quantum physics
nucleotide pair
superexchange
Hopping
tunneling
Online Access:Get full text
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Summary:The paper examines thedynamical behavior of a radical cation(G(+*)) generated in adouble stranded DNA for differentoligonucleotide sequences. The resonancehole tunneling through an oligonucleotidesequence is studied by the method ofnumerical integration of self-consistentquantum-mechanical equations. The holemotion is considered quantum mechanicallyand nucleotide base oscillations aretreated classically. The results obtaineddemonstrate a strong dependence of chargetransfer on the type of nucleotidesequence. The rates of the hole transferare calculated for different nucleotidesequences and compared with experimentaldata on the transfer from (G(+*))to a GGG unit.
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ISSN:0092-0606
1573-0689
DOI:10.1023/B:JOBP.0000035844.35839.60