Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters

The granule cell population response to perforant path stimulation decreased significantly within seconds following release of endogenous dynorphin from dentate granule cells. The depression was blocked by the opioid receptor antagonists naloxone and norbinaltorphimine, suggesting that the effect wa...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 14; no. 6; pp. 3736 - 3750
Main Authors:	Drake, CT, Terman, GW, Simmons, ML, Milner, TA, Kunkel, DD, Schwartzkroin, PA, Chavkin, C
Format:	Journal Article
Language:	English
Published:	United States Soc Neuroscience 01-06-1994 Society for Neuroscience
Subjects:	Animals Dynorphins - metabolism Dynorphins - physiology Endorphins - metabolism Endorphins - physiology Granulocytes - metabolism Guinea Pigs Hippocampus - cytology Hippocampus - metabolism Immunohistochemistry Male Microscopy, Electron Neural Inhibition - physiology Neurotransmitter Agents - physiology Time Factors Tissue Distribution
Online Access:	Get full text
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