Antiepileptic effects of CNK-602A, a novel thyrotropin-releasing hormone analog, on absence-like and tonic seizures of spontaneously epileptic rats

The effects of CNK-602A (N-[(6-methyl-5-oxo-3-thiomorpholinyl) carbonyl]-L-histidyl-L-prolinamide), a novel thyrotropin-releasing hormone related analog, were investigated on absence-like seizure and tonic convulsion in the spontaneously epileptic rat (SER), which is a genetically defined double-mut...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 223; no. 2-3; p. 185
Main Authors:	Renming, X, Ishihara, K, Sasa, M, Ujihara, H, Momiyama, T, Fujita, Y, Todo, N, Serikawa, T, Yamada, J, Takaori, S
Format:	Journal Article
Language:	English
Published:	Netherlands 17-11-1992
Subjects:	Animals Caudate Nucleus - drug effects Caudate Nucleus - metabolism Cerebral Cortex - drug effects Cerebral Cortex - physiopathology Dose-Response Relationship, Drug Electroencephalography Epilepsy - drug therapy Epilepsy - physiopathology Female Haloperidol - pharmacology Hippocampus - drug effects Hippocampus - physiopathology Male Rats Seizures - drug therapy Seizures - physiopathology Thyrotropin-Releasing Hormone - analogs & derivatives Thyrotropin-Releasing Hormone - pharmacology
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