The effects of endogenous non-peptide molecule isatin and hydrogen peroxide on proteomic profiling of rat brain amyloid-β binding proteins: relevance to Alzheimer's disease?

The amyloid-β peptide is considered as a key player in the development and progression of Alzheimer's disease (AD). Although good evidence exists that amyloid-β accumulates inside cells, intracellular brain amyloid-binding proteins remain poorly characterized. Proteomic profiling of rat brain h...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 16; no. 1; pp. 476 - 495
Main Authors:	Medvedev, Alexei E, Buneeva, Olga A, Kopylov, Arthur T, Gnedenko, Oksana V, Medvedeva, Marina V, Kozin, Sergey A, Ivanov, Alexis S, Zgoda, Victor G, Makarov, Alexander A
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 29-12-2014 MDPI AG
Subjects:	Actins - metabolism Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism amyloid-β amyloid-β binding proteins Animals Brain - metabolism Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Hydrogen Peroxide - metabolism isatin Isatin - metabolism Male oxidative stress Protein Binding Protein Interaction Maps proteomic profiling Proteomics rat brain Rats
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