Adult adrenal neuroblastoma: A case report

• Published in: Molecular and clinical oncology Vol. 15; no. 5
• Main Authors: Xu, Shenghan, Zhang, Wenjun, Che, Bangwei, Zhang, Jinjuan, He, Jun, Liu, Dongdong, Chen, Pan, Mu, Yi, Chen, Kehang, Tang, Kaifa
• Format: Journal Article
• Language: English
• Published: Athens Spandidos Publications 01-11-2021; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Abdomen; Adults; Biological products; Brain; Calcification; Carboplatin; Case reports; Cell growth; Chemotherapy; Diagnosis; Disease; Drug dosages; Immunohistochemistry; Kinases; Laboratories; Laparoscopy; Magnetic resonance imaging; Medical prognosis; Medical research; Metastasis; Nanoparticles; Nervous system; Neuroblastoma; Neuroendocrine tumors; Oncology; Pain; Patients; Radiation therapy; Rare diseases; Substance abuse treatment; Surgery; Canada; China
• DOI: 10.3892/mco.2021.2378
• EISSN: 2049-9469
• ISSN: 2049-9450

Adrenal neuroblastoma (NB) is very rare in adults. According to the literature, <100 cases have been reported worldwide to date, with >90% of the patients aged <10 years. As the early symptoms of the disease are not obvious, distant metastasis has often already occurred when the patients develop clinical symptoms. This lack of obvious symptoms may lead to misdiagnosis and inadequate treatment. Imaging and laboratory examinations are crucial for the diagnosis of NB, but reaching a definitive diagnosis prior to surgery is challenging, as the final diagnosis ultimately depends on histopathological examination. The aim of the present study was to report the rare case of a 40-year-old woman with adrenal left NB who underwent tumor resection. No tumor recurrence was observed at the 3-month and 1-year postoperative follow-up, but a repeat computed tomography at the 3-year postoperative follow-up indicated metastases; the patient refused further treatment and eventually succumbed to the disease within 1 month. The aim of the present case was to emphasize the importance of individualized therapy and long-term, close follow-up of the patients. The clinical characteristics and treatment of this case of adrenal NB were also summarized and analyzed in order to raise clinical awareness of this rare disease.