Nelarabine: A novel purine antimetabolite antineoplastic agent

Abstract Background: Nelarabine was approved by the US Food and Drug Administration (FDA) in October 2005 for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) that has not responded to or has relapsed after treatment with at least 2 chemotherapy...

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Bibliographic Details
Published in:	Clinical therapeutics Vol. 29; no. 9; pp. 1887 - 1899
Main Authors:	Buie, Larry W., PharmD, Epstein, Stacy S., PharmD, Lindley, Celeste M., PharmD
Format:	Journal Article
Language:	English
Published:	Belle Mead, NJ EM Inc USA 01-09-2007 Excerpta Medica Elsevier Limited
Subjects:	Adenosine Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use ara-G ara-GTP Arabinonucleosides - administration & dosage Arabinonucleosides - adverse effects Arabinonucleosides - pharmacology Arabinonucleosides - therapeutic use Arranon Biological and medical sciences Cancer Cytotoxicity Drug Resistance, Neoplasm Drug therapy Hematologic and hematopoietic diseases Hematologic Neoplasms - drug therapy Humans Internal Medicine Leukemia Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lymphoma, T-Cell - drug therapy Medical Education Medical sciences Metabolism nelarabine Oncology Pharmacokinetics Pharmacology. Drug treatments Pharmacy purine nucleoside analogue Purine Nucleosides - administration & dosage Purine Nucleosides - adverse effects Purine Nucleosides - pharmacology Purine Nucleosides - therapeutic use North Carolina United States > US leukemia ara-G purine nucleoside analogue ara-GTP lymphoma Arranon nelarabine Antineoplastic agent GTP Purine nucleoside Leukemia Malignant hemopathy Lymphoid neoplasm Lymphoma Nelarabine Antimetabolic Lymphoproliferative syndrome Analog
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