Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions

Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions

Highlights • Transcriptome studies suggest miRNAs can be used as microglia phenotype markers. • MiR-124 regulates the quiescent state of microglia in the brain. • The immune role of miR-146a and miR-155 depends on the type of brain injury. • Transcription kinetics of miRNAs/target mRNAs control miRN...

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Bibliographic Details
Published in:Current opinion in pharmacology Vol. 26; no. C; pp. 1 - 9
Main Authors: Cardoso, Ana L, Guedes, Joana R, de Lima, Maria C Pedroso
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-02-2016
Elsevier
Subjects:
Animals
Brain - immunology
Humans
Immunity, Innate
Internal Medicine
Medical Education
MicroRNAs - immunology
Neurogenic Inflammation - immunology
Neuroimmunomodulation
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Summary:Highlights • Transcriptome studies suggest miRNAs can be used as microglia phenotype markers. • MiR-124 regulates the quiescent state of microglia in the brain. • The immune role of miR-146a and miR-155 depends on the type of brain injury. • Transcription kinetics of miRNAs/target mRNAs control miRNA immune regulatory role.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
USDOE Office of Nuclear Energy (NE), Nuclear Fuel Cycle and Supply Chain
PTDC/BIM-MEC/0651/2012; UID/NEU/04539/2013; SFRH/BD/51677/2011
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2015.09.001