Preventive strategy for nonalcoholic fatty liver disease-related hepatocellular carcinoma

• Published in: Clinical and molecular hepatology Vol. 29; no. Suppl; pp. S220 - S227
• Main Authors: Cho, Yuri, Kim, Bo Hyun, Park, Joong-Won
• Format: Journal Article Book Review
• Language: English
• Published: Korea (South) Korean Association for the Study of the Liver 01-02-2023; The Korean Association for the Study of the Liver
• Subjects: Aspirin; Body mass index; Cancer therapies; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - prevention & control; Coffee; Cytokines; Diabetes; Diet; Disease prevention; Exercise; Fatty acids; Growth factors; hepatocellular carcinoma; Humans; Inflammation; Insulin resistance; Kinases; Liver cancer; Liver cirrhosis; Liver diseases; Liver Neoplasms - complications; Liver Neoplasms - prevention & control; Metabolic syndrome; Metabolites; Non-alcoholic Fatty Liver Disease - pathology; nonalcoholic fatty liver disease; Obesity; Pathogenesis; prevention; Review; Risk factors; surveillance; Vitamin deficiency; Weight control; United States > US; Prevention; Hepatocellular carcinoma; Nonalcoholic fatty liver disease; Surveillance
• ISSN: 2287-2728; 2287-285X
• DOI: 10.3350/cmh.2022.0360

The incidence of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide, including Asia. Most patients with NAFLD-related HCC are at a much-advanced stage and older age at the time of diagnosis than those with virus-related HCC because they have not undergone HCC surveillance. This review provides an overview of the mechanism of hepatocarcinogenesis in NAFLD, preventive strategies for NAFLDrelated HCC, and strategies for the surveillance of patients with NAFLD.