Clinicopathologic analysis of 7 cases of oral schwannoma and review of the literature

• Published in: Annals of diagnostic pathology Vol. 14; no. 4; pp. 235 - 239
• Main Authors: Santos, Pedro Paulo de Andrade, DDS, MSc, Freitas, Valéria Souza, DDS, MSc, Pinto, Leão Pereira, DDS, PhD, Freitas, Roseana de Almeida, DDS, PhD, de Souza, Lélia Batista, DDS, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-08-2010
• Subjects: Adolescent; Adult; Benign tumor; Child; Female; Humans; Male; Middle Aged; Mouth Neoplasms - pathology; Mouth Neoplasms - surgery; Neural tumor; Neurilemmoma; Neurilemmoma - pathology; Neurilemmoma - surgery; Pathology; Schwannoma; Young Adult; Neural tumor; Neurilemmoma; Benign tumor; Schwannoma
• ISSN: 1092-9134; 1532-8198
• DOI: 10.1016/j.anndiagpath.2010.02.009

Abstract Schwannomas, also known as neurilemmomas, are uncommon neoplasms apparently derived from Schwann cells. The growth of these tumors causes displacement and compression of the nerve of origin. Schwannomas are usually solitary lesions but can be multiple when associated with neurofibromatosis. Anti-S100 protein is the most widely used antibody for the identification of this neoplasm. Surgical excision is the treatment of choice for schwannomas, with few and controversial reports of recurrence or malignant transformation. The present article reports 7 additional cases of oral schwannoma, and the literature is reviewed regarding clinicopathologic features, immunohistochemical findings, differential diagnosis, and therapeutic management of this benign neural tumor.