Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder

Numerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responders to medication (40–60%). Our study is the largest investig...

Full description

Saved in:
Bibliographic Details
Published in:The pharmacogenomics journal Vol. 14; no. 2; pp. 176 - 181
Main Authors: Brandl, E J, Tiwari, A K, Zhou, X, Deluce, J, Kennedy, J L, Müller, D J, Richter, M A
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01-04-2014
Nature Publishing Group
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Numerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responders to medication (40–60%). Our study is the largest investigation to date ( N =184) of treatment response and side effects to antidepressants in OCD based on metabolizer status for CYP2D6 and CYP2C19. We observed significantly more failed medication trials in CYP2D6 non-extensive compared with extensive metabolizers ( P =0.007). CYP2D6 metabolizer status was associated with side effects to venlafaxine ( P =0.022). There were nonsignificant trends for association of CYP2D6 metabolizer status with response to fluoxetine ( P =0.056) and of CYP2C19 metabolizer status with response to sertraline ( P =0.064). Our study is the first to indicate that CYP genes may have a role in antidepressant response in OCD. More research is required for a future clinical application of genetic testing, which could lead to improved treatment outcomes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1470-269X
1473-1150
DOI:10.1038/tpj.2013.12