Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder
Numerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responders to medication (40–60%). Our study is the largest investig...
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Published in: | The pharmacogenomics journal Vol. 14; no. 2; pp. 176 - 181 |
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Main Authors: | , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
London
Nature Publishing Group UK
01-04-2014
Nature Publishing Group |
Subjects: | |
Online Access: | Get full text |
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Summary: | Numerous studies have reported on pharmacogenetics of antidepressant response in depression. In contrast, little is known of response predictors in obsessive-compulsive disorder (OCD), a disorder with among the lowest proportion of responders to medication (40–60%). Our study is the largest investigation to date (
N
=184) of treatment response and side effects to antidepressants in OCD based on metabolizer status for CYP2D6 and CYP2C19. We observed significantly more failed medication trials in CYP2D6 non-extensive compared with extensive metabolizers (
P
=0.007). CYP2D6 metabolizer status was associated with side effects to venlafaxine (
P
=0.022). There were nonsignificant trends for association of CYP2D6 metabolizer status with response to fluoxetine (
P
=0.056) and of CYP2C19 metabolizer status with response to sertraline (
P
=0.064). Our study is the first to indicate that
CYP
genes may have a role in antidepressant response in OCD. More research is required for a future clinical application of genetic testing, which could lead to improved treatment outcomes. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1470-269X 1473-1150 |
DOI: | 10.1038/tpj.2013.12 |