Crystal structure of human CDC7 kinase in complex with its activator DBF4

The kinase CDC7 is essential for replication initiation in eukaryote organisms. To exert its function, CDC7 requires its activator, DBF4. Now the crystal structures of a minimal CDC7–DBF4 complex, with bound nucleotide or inhibitor, along with functional analyses reveal that DBF4 wraps around CDC7,...

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Bibliographic Details
Published in:	Nature structural & molecular biology Vol. 19; no. 11; pp. 1101 - 1107
Main Authors:	Hughes, Siobhan, Elustondo, Frédéric, Di Fonzo, Andrea, Leroux, Frédéric G, Wong, Ai C, Snijders, Ambrosius P, Matthews, Stephen J, Cherepanov, Peter
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-11-2012 Nature Publishing Group
Subjects:	631/45/275 631/45/535 Amino Acid Sequence ATP Biochemistry Biological Microscopy Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Crystal structure Crystallization Deoxyribonucleic acid DNA DNA replication Humans Kinases Life Sciences Magnetic Resonance Spectroscopy Membrane Biology Models, Molecular Molecular biology Molecular Sequence Data Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Physiological aspects Protein Conformation Protein kinases Protein Structure Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - metabolism Structure X-Ray Diffraction United Kingdom
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