Survival after surgery for hepatocellular carcinoma in relation to presence or absence of viral infection

• Published in: The American journal of surgery Vol. 206; no. 2; pp. 187 - 193
• Main Authors: Ishizuka, Mitsuru, M.D, Kubota, Keiichi, M.D, Kita, Junji, M.D, Shimoda, Mitsugi, M.D, Kato, Masato, M.D, Sawada, Tokihiko, M.D
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-08-2013; Elsevier Limited
• Subjects: Adult; Aged; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - surgery; Carcinoma, Hepatocellular - virology; Databases, Factual; Disease-Free Survival; Fatty Liver - complications; Female; Hepatitis B - complications; Hepatitis B virus; Hepatitis C - complications; Hepatitis C virus; Hepatocellular carcinoma; Humans; Infections; Kaplan-Meier Estimate; Liver cancer; Liver cirrhosis; Liver Neoplasms - mortality; Liver Neoplasms - surgery; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Postoperative survival; Predictive Value of Tests; Prognosis; Retrospective Studies; Surgery; Treatment Outcome; Viral infection; Viral infections; Hepatocellular carcinoma; Hepatitis B virus; Hepatitis C virus; Viral infection; Postoperative survival
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/j.amjsurg.2012.08.011

Abstract Background The aim of this study was to compare postoperative survival between hepatocellular carcinoma (HCC) patients with and without viral infection. Methods From among 398 HCC patients in our collected database, 377 who underwent surgery were enrolled. The patients were divided into 2 groups: group 1, those who had no hepatitis B virus or hepatitis C virus infection, and group 2, those who had hepatitis B virus or hepatitis C virus infection. Univariate analysis was performed to compare clinical factors, including viral infection, with overall survival. Kaplan-Meier analysis and the log-rank test were used to evaluate the overall and disease-free survival curves for the 2 groups. Results Univariate analysis showed that viral infection showed no such association. Moreover, Kaplan-Meier analysis and the log-rank test revealed no significant intergroup differences in either overall or disease-free survival. Conclusions The presence or absence of viral infection shows no significant association with the postoperative survival of patients undergoing surgery for HCC.