A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping

Condensin I is a five-subunit protein complex that is central to mitotic chromosome assembly in eukaryotic cells. Despite recent progress, its molecular mechanisms of action remain to be fully elucidated. By using Xenopus egg extracts as a functional assay, we find that condensin I complexes harbori...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 221; no. 3; p. 1
Main Authors:	Kinoshita, Kazuhisa, Tsubota, Yuko, Tane, Shoji, Aizawa, Yuuki, Sakata, Ryota, Takeuchi, Kozo, Shintomi, Keishi, Nishiyama, Tomoko, Hirano, Tatsuya
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 07-03-2022
Subjects:	Adenosine triphosphatase Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Amino Acid Motifs Animals Assembly Beans Biochemistry Biophysics Cell Cycle and Division Chromatin or Epigenetics Chromosomal Proteins, Non-Histone - metabolism Chromosomes Chromosomes - metabolism Condensin DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Eggs Extrusion Humans Mice Molecular modelling Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Mutation Mutation - genetics Phenotype Phenotypes Protein Structure, Secondary Structure-Activity Relationship Xenopus
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