Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix

TGIF1 is a transcriptional repressor playing crucial roles in human development and function and is associated with holoprosencephaly and various cancers. TGIF1-directed transcriptional repression of specific genes depends on the recruitment of corepressor SIN3A. However, to date, the exact region o...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 22; no. 23; p. 12631
Main Authors:	He, Xiaoling, Nie, Yao, Zhou, Heng, Hu, Rui, Li, Ying, He, Ting, Zhu, Jiang, Yang, Yunhuang, Liu, Maili
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 23-11-2021 MDPI
Subjects:	Binding Binding Sites Circular Dichroism Dimerization Domains Gene silencing Genes HeLa Cells Holoprosencephaly Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homology Humans Hydrophobicity intrinsically disordered protein Models, Molecular molecular modeling Mutation nuclear magnetic resonance (NMR) Peptide inhibitors Protein Binding Protein Domains Protein Structure, Secondary protein–protein interaction Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Residues Scattering, Small Angle Sin3 Histone Deacetylase and Corepressor Complex - chemistry Sin3 Histone Deacetylase and Corepressor Complex - genetics Sin3 Histone Deacetylase and Corepressor Complex - metabolism Spectrum analysis Structure-function relationships transcription repressor Yeast protein–protein interaction transcription repressor intrinsically disordered protein molecular modeling nuclear magnetic resonance (NMR)
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