Endogenous Modulation of Extracellular Matrix Collagen during Scar Formation after Myocardial Infarction

Myocardial infarction is remains the leading cause of death in developed countries. Recent data show that the composition of the extracellular matrix might differ despite similar heart function and infarction sizes. Because collagen is the main component of the extracellular matrix, we hypothesized...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 23; p. 14571
Main Authors:	Schumacher, David, Curaj, Adelina, Staudt, Mareike, Simsekyilmaz, Sakine, Kanzler, Isabella, Boor, Peter, Klinkhammer, Barbara Mara, Li, Xiaofeng, Bucur, Octavian, Kaabi, Adnan, Xu, Yichen, Zheng, Huabo, Nilcham, Pakhwan, Schuh, Alexander, Rusu, Mihaela, Liehn, Elisa A
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 23-11-2022 MDPI
Subjects:	Angiogenesis Angiotensin Angiotensin II CCR1 protein CCR2 protein Cicatrix - pathology Collagen Collagen - genetics Collagen - metabolism Collagen Type I - metabolism Composition Differentiation Ejection fraction Extracellular matrix Extracellular Matrix - metabolism Fibroblasts Fibroblasts - metabolism Gene expression Genes Heart attacks Heart function Humans Inflammation Interleukin 1 Leukocytes (mononuclear) Leukocytes (neutrophilic) Monocyte chemoattractant protein 1 Morphology Myocardial infarction Myocardial Infarction - metabolism Myocardium - metabolism Myofibroblasts - metabolism Neutrophils NF-κB protein remodeling RNA, Messenger - metabolism scar formation Smooth muscle Stiffness remodeling inflammation extracellular matrix myocardial infarction scar formation
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