Stunting correlates with high salivary and serum antibody levels after 13-valent pneumococcal conjugate vaccination of Venezuelan Amerindian children

• Published in: Vaccine Vol. 34; no. 20; pp. 2312 - 2320
• Main Authors: Verhagen, Lilly M, Hermsen, Meyke, Rivera-Olivero, Ismar, Sisco, María Carolina, Pinelli, Elena, Hermans, Peter W.M, Berbers, Guy A.M, Waard, Jacobus H. de, Jonge, Marien I. de
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 29-04-2016; Elsevier Limited
• Subjects: 13-Valent pneumococcal conjugate vaccination; Age; Allergy and Immunology; Antibodies, Bacterial - blood; Antibodies, Bacterial - chemistry; Child, Preschool; Chronic malnutrition; Community; Cross-Sectional Studies; Female; Growth Disorders - immunology; Humans; Immunoglobulin G - blood; Immunoglobulin G - chemistry; Immunoglobulins; Indigenous children; Infant; Linear Models; Male; Malnutrition; Malnutrition - immunology; Nutritional Status; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - administration & dosage; Pneumonia; Regression analysis; Saliva; Saliva - chemistry; Serogroup; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - classification; Vaccines; Vaccines, Conjugate - administration & dosage; Vaccines, Conjugate - therapeutic use; Venezuela; Venezuela; Venezuela; Chronic malnutrition; Indigenous children; Saliva; 13-Valent pneumococcal conjugate vaccination
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2016.03.066

Highlights • In Venezuelan children, PCV13 salivary and serum antibody levels correlated well. • Saliva may be used as a read-out for PCV13 vaccine response. • Stunted children had higher specific serum and salivary PCV13 antibody levels. • More studies addressing the effect of malnutrition on vaccine induced responses are needed.