Stimulation of nerve growth factor (NGF) synthesis by tryptophan and its metabolites in cultured mouse astroglial cells

• Published in: Bioscience, biotechnology, and biochemistry Vol. 58; no. 11; pp. 2116 - 2117
• Main Authors: Nakano, K. (Nagoya Univ. (Japan)), Kondo, H, Hattori, M, Tsubouchi, S, Furukawa, S
• Format: Journal Article
• Language: English
• Published: Tokyo Taylor & Francis 1994; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: ALIMENTOS; Analytical, structural and metabolic biochemistry; ANIMAL GROWTH PROMOTERS; Biological and medical sciences; FOODS; Fundamental and applied biological sciences. Psychology; MICE; NERVOUS SYSTEM DISEASES; PRODUIT ALIMENTAIRE; PROMOTEUR DE CROISSANCE ANIMALE; PROMOTORES DEL CRECIMIENTO ANIMAL; Protein hormones. Growth factors. Cytokines; Proteins; RATON; SOURIS; TRASTORNOS DEL SISTEMA NERVIOSO; TRIPTOFANO; TROUBLE DU SYSTEME NERVEUX; TRYPTOPHAN; TRYPTOPHANE; Metabolite; Rodentia; Tryptophan; Nerve growth factor; Biosynthesis; In vitro; Vertebrata; Mammalia; Astroglia; Mouse; Polypeptide; Metabolic activation; Growth factor
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.58.2116

Effects of l-tryptophan and its metabolites were evaluated on synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells. l-Tryptophan stimulated NGF production in a dose-dependent fashion. Serotonin and quinolinic acid slightly increased NGF synthesis. l-Kynurenine had a marked stimulatory effect on NGF synthesis at a dose of 100 μm. In contrast, kynurenic acid had no effect.