The role of telomeres in predicting individual radiosensitivity of patients with cancer in the era of personalized radiotherapy

• Published in: Cancer treatment reviews Vol. 41; no. 4; pp. 354 - 360
• Main Authors: Mirjolet, Céline, Boidot, Romain, Saliques, Sébastien, Ghiringhelli, François, Maingon, Philippe, Créhange, Gilles
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-04-2015
• Subjects: Animals; Chromosome instability; Hematology, Oncology and Palliative Medicine; Humans; Ionizing radiations; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - radiotherapy; Personalized medicine; Precision Medicine - methods; Predictive Value of Tests; Radiation Tolerance - genetics; Radiobiology; Telomerase; Telomere; Telomere - genetics; Telomere - metabolism; H2AX; XCRCC4 like factor; Mre11-Rad50-NBS1 complex; alternative non-homologous end joining; RNA; DNA damage response; base pair; PTEN; ALT; HRR; double-strand breaks; NBN/NBS1, NLRP2; SMC1; ataxia telangiectasia mutated; Mre11; Radiobiology; Telomerase; tripeptidyl-peptidase 1; UV; IR; phosphatase and tensin homolog; Personalized medicine; meiotic recombination 11 homolog A; ultra violet; MRN complex; X-ray repair complementing defective repair in Chinese hamster cells 3/4; TRF1-interacting nuclear protein 2; alternative lengthening of telomeres; DNA PK; radiation therapy; TRF1/2; Pot1; hTERT; human telomerase reverse transcriptase; telomere loop; telomeric repeat binding factor 1/2; ionizing radiation; kilo base; ribonucleic acid; RT; t-loop; Ionizing radiations; TERC; PML nuclear bodies; Telomere; bp; eukaryotic homolog of the prokaryotic RecA protein 50; 8-oxodG; DNA-dependent protein kinases; protection of telomere 1; DDR; XLF; deoxyribonucleic acid; homologous recombination repair; kb; C-NHEJ; classical non-homologous end joining; XRCC3/4; DSBs; H2A histone family, member X; telomerase RNA component; Rad50; A-NHEJ; structural maintenance of chromosome 1; 8-oxo-7,8-dihydro-2′-deoxyguanosine; human epidermal growth factor receptor 2; NLR family, pyrin domain containing 2; Chromosome instability; promyelocytic leukemia nuclear bodies; repressor-activator protein 1; DNA; Rap1; ATM; TPP1; HER2; Tin2
• ISSN: 0305-7372; 1532-1967
• DOI: 10.1016/j.ctrv.2015.02.005

Highlights • Telomeres play a role in the era of personalized radiotherapy. • Telomere length of cancer cells may be a reliable marker of radiotherapy efficacy. • Telomere length of lymphocytes or normal somatic cells as a marker of radiotherapy tolerance. • Quantifying telomere length might help clinicians in therapeutic decision-making.