Acetylcholine-Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors
Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene‐ or pillarene‐based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled b...
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Published in: | Chemistry : a European journal Vol. 20; no. 11; pp. 2998 - 3004 |
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Main Authors: | , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Weinheim
WILEY-VCH Verlag
10-03-2014
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
Subjects: | |
Online Access: | Get full text |
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Summary: | Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene‐ or pillarene‐based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof‐of‐concept study is far from a real‐life application, it provides a possible route to treat diseases related to the central nervous system.
Supramolecular nanovalves: Mesoporous silica nanoparticles (MSNs) equipped with calixarene‐ or pillarene‐based nanovalves were prepared and characterized (see scheme). Acetylcholine (ACh), a neurotransmitter, successfully triggered cargo release from the nanocontainers, which could be useful for Parkinson's disease (PD) treatment. |
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Bibliography: | ark:/67375/WNG-Q1FV91Q8-8 ArticleID:CHEM201304864 National Natural Science Foundation - No. 21272093 istex:3BD0A759009DE899DDFC8D8B044E9CC854E553D1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0947-6539 1521-3765 |
DOI: | 10.1002/chem.201304864 |