Acetylcholine-Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors

Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene‐ or pillarene‐based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled b...

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Bibliographic Details
Published in:Chemistry : a European journal Vol. 20; no. 11; pp. 2998 - 3004
Main Authors: Zhou, Yue, Tan, Li-Li, Li, Qing-Lan, Qiu, Xi-Long, Qi, Ai-Di, Tao, Yanchun, Yang, Ying-Wei
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 10-03-2014
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
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Summary:Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene‐ or pillarene‐based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof‐of‐concept study is far from a real‐life application, it provides a possible route to treat diseases related to the central nervous system. Supramolecular nanovalves: Mesoporous silica nanoparticles (MSNs) equipped with calixarene‐ or pillarene‐based nanovalves were prepared and characterized (see scheme). Acetylcholine (ACh), a neurotransmitter, successfully triggered cargo release from the nanocontainers, which could be useful for Parkinson's disease (PD) treatment.
Bibliography:ark:/67375/WNG-Q1FV91Q8-8
ArticleID:CHEM201304864
National Natural Science Foundation - No. 21272093
istex:3BD0A759009DE899DDFC8D8B044E9CC854E553D1
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201304864