Session 2: Are we ready for primary chemotherapy in rectal cancer: who, when, why?

• Published in: Colorectal disease Vol. 20; no. S1; pp. 56 - 60
• Main Authors: Patel, U. B., Cervantes, A., Fernández‐Martos, C., Sclafani, F., Cunningham, D., Nilsson, P., Brown, G.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-05-2018
• Subjects: Cancer; Chemoradiotherapy; Chemotherapy; Clinical trials; Medicin och hälsovetenskap; Preoperative chemotherapy; Radiation therapy; Rectal Cancer; Rectum; Tumors; Preoperative chemotherapy; Rectal Cancer
• ISSN: 1462-8910; 1463-1318; 1463-1318
• DOI: 10.1111/codi.14081

The potential of preoperative chemotherapy in rectal cancer is the subject of investigation in a number of global randomized trials. In this overview and expert discussion, Professor Cervantes summarizes the findings of numerous Phase II trials testing neoadjuvant chemotherapy. The crucial points in the next phase of trials include: patient selection, whether radiotherapy can be omitted altogether and whether chemotherapy can be used to augment the initial response to chemoradiotherapy. Finally, with the emergence of Magnetic Resonance Tumour Regression Grade a reliable method for assessing response after initial chemoradiotherapy, we ask if this can be used to drive the use of further selective chemotherapy to augment response.