Sustained Inhibition of Proliferative Response After Transient FGF Stimulation Is Mediated by Interleukin 1 Signaling

Transient FGF stimulation of various cell types results in FGF memory—a sustained blockage of efficient proliferative response to FGF and other growth factors. FGF memory establishment requires HDAC activity, indicating its epigenetic character. FGF treatment stimulates proinflammatory NFκB signalin...

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Bibliographic Details

Published in:	Journal of cellular physiology Vol. 231; no. 3; pp. 650 - 658
Main Authors:	Poole, Ashleigh, Kacer, Doreen, Cooper, Emily, Tarantini, Francesca, Prudovsky, Igor
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-03-2016 Wiley Subscription Services, Inc
Subjects:	Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Cell Proliferation - drug effects Cells, Cultured Fibroblast Growth Factors - metabolism Fibroblast Growth Factors - pharmacology Growth factors Interleukin-1 - metabolism Mice NF-kappa B - metabolism Signal Transduction - drug effects
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