Fast liquid chromatography–tandem mass spectrometry for the analysis of bisphenol A-diglycidyl ether, bisphenol F-diglycidyl ether and their derivatives in canned food and beverages

• Published in: Journal of Chromatography A Vol. 1218; no. 12; pp. 1603 - 1610
• Main Authors: Gallart-Ayala, H., Moyano, E., Galceran, M.T.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 25-03-2011; Amsterdam; New York: Elsevier; Elsevier
• Subjects: Benzhydryl Compounds; Biological and medical sciences; Bisphenol A; Bisphenol A diglycidyl ethers (BADGEs); Bisphenol F diglycidyl ethers (BFDGEs); Bisphenols; Canned food; Carbonated Beverages - analysis; Cartridges; Chromatography; Chromatography, Liquid - methods; Epoxy Compounds - analysis; Ethers; Food Analysis - methods; Food industries; Food, Preserved - analysis; Foods; Fundamental and applied biological sciences. Psychology; Fused Core; General aspects; Liquid chromatography; Mass spectrometry; Methods of analysis, processing and quality control, regulation, standards; Soft drinks; Solid Phase Extraction; Tandem mass spectrometry; Tandem Mass Spectrometry - methods; Bisphenol F diglycidyl ethers (BFDGEs); Tandem mass spectrometry; Fused Core; Canned food; Bisphenol A diglycidyl ethers (BADGEs); Soft drinks; Solid phase extraction; Chemical analysis; HPLC chromatography; Epoxy resin; Solvent extraction; Porous material; Electrospray; Peroxisome proliferator; Quadrupole spectrometer; Chemical enrichment; Bisphenol A diglycidyl ethers (BADGES); Sample preparation; Soft drink; Quantitative analysis; Stationary phase; Canned product; Liquid liquid extraction; Coupled method; Core-shell particle; Contamination; Carcinogen; Column packing; Residue; Simultaneous measurement
• ISSN: 0021-9673; 1873-3778
• DOI: 10.1016/j.chroma.2011.01.026

In this work a fast liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) method using a C18 Fused Core™ column, was developed for the simultaneous analysis of bisphenol A diglycidyl ether (BADGE), bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE·H
2O), bisphenol A bis(2,3-dihydroxypropyl) ether (BADGE·2H
2O), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether (BADGE·HCl), bisphenol A bis(3-chloro-2-hydroxypropyl) ether (BADGE·2HCl) and bisphenol A (3-chloro-2-hydroxypropyl)(2,3-dihydroxypropyl ether) (BADGE·HCl·H
2O) and bisphenol F diglycidyl ether (BFDGE), bisphenol F bis(2,3-dihydroxypropyl) ether (BFDGE·2H
2O), bisphenol F bis(3-chloro-2-hydroxypropyl) ether (BFDGE·2HCl). The LC method was coupled with a triple quadrupole mass spectrometer, using an ESI source in positive mode and using the [M+NH
4]
+ adduct as precursor ion for tandem mass spectrometry experiments. The method developed was applied to the determination of these compounds in canned soft drinks and canned food. OASIS HLB solid phase extraction (SPE) cartridges were used for the analysis of soft drinks, while solid canned food was extracted with ethyl acetate. Method limits of quantitation ranged from 0.13
μg
L
−1 to 1.6
μg
L
−1 in soft drinks and 1.0
μg
kg
−1 to 4.0
μg
kg
−1 in food samples. BADGE·2H
2O was detected in all the analyzed samples, while other BADGEs such as BADGE·H
2O, BADGE·HCl·H
2O, BADGE·HCl and BADGE·2HCl were also detected in canned foods.