Interleukin-6 and tumor necrosis factor-alpha gene polymorphisms in chronic idiopathic urticaria

• Published in: Allergologia et immunopathologia Vol. 42; no. 6; p. 533
• Main Authors: Tavakol, M, Amirzargar, A A, Movahedi, M, Aryan, Z, Bidoki, A Z, Gharagozlou, M, Aghamohammadi, A, Nabavi, M, Ahmadvand, A, Behniafard, N, Heidari, K, Soltani, S, Rezaei, N
• Format: Journal Article
• Language: English
• Published: Spain 01-11-2014
• Subjects: Chronic Disease; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-6 - genetics; Iran; Male; Polymorphism, Single Nucleotide; Promoter Regions, Genetic - genetics; Tumor Necrosis Factor-alpha - genetics; Urticaria - genetics; Urticaria - immunology; Iran; Interleukin 6; Tumor necrosis factor alpha; Single nucleotide polymorphism; Urticaria
• ISSN: 1578-1267
• DOI: 10.1016/j.aller.2013.06.004

This study was performed to evaluate association of gene polymorphisms among proinflammatory cytokines and susceptibility to chronic idiopathic urticaria (CIU).
Ninety patients with prolonged urticaria more than 6 weeks were included as case group. Single nucleotide polymorphisms (SNPs) of IL-6 (G/C -174, G/A nt565) and TNF-α (G/A -308, G/A -238) were evaluated, using polymerase chain reaction (PCR); and the results were compared to the control group.
G allele was significantly higher in the patients at locus of -238 of promoter of TNF-α gene (p<0.001). Frequency of following genotypes were significantly lower in patients with CIU, compared to controls: AG at -308 and GA at -238 of TNF-α gene (p<0.05 and p<0.001, respectively), CG at -174 and GG at +565 of IL-6 gene (p<0.05). Additionally, following genotypes were more common among patients with CIU: GG at -308 and -238 of TNF-α gene (p<0.05 and p<0.001, respectively), GG at -174 and GA at +565 of IL-6 gene (p<0.05).
Pro-inflammatory cytokine gene polymorphisms can affect susceptibility to CIU. TNF-α promoter polymorphisms as well as IL-6 gene polymorphisms are associated with CIU.