Flippases: still more questions than answers
Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. M...
Saved in:
| Published in: | Cellular and molecular life sciences : CMLS Vol. 65; no. 20; pp. 3119 - 3125 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Basel
Basel : SP Birkhäuser Verlag Basel
01-10-2008
Birkhäuser-Verlag Springer Nature B.V |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. Most importantly, biochemical characterization of P₄-ATPases is required in order to clarify whether these transporters indeed are capable of catalyzing transmembrane phospholipid flipping. The β-subunit of P₄-ATPases shows unexpected similarities between the β- and γ-subunits of the Na⁺/K⁺-ATPase. It is likely that these proteins provide a similar solution to similar problems, and might have adopted similar structures to accomplish these tasks. No P₄-ATPases have been identified in the endoplasmic reticulum and it remains an intriguing possibility that, in this compartment, P₅A-ATPases are functional homologues of P₄-ATPases. |
|---|---|
| AbstractList | Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. Most importantly, biochemical characterization of P₄-ATPases is required in order to clarify whether these transporters indeed are capable of catalyzing transmembrane phospholipid flipping. The β-subunit of P₄-ATPases shows unexpected similarities between the β- and γ-subunits of the Na⁺/K⁺-ATPase. It is likely that these proteins provide a similar solution to similar problems, and might have adopted similar structures to accomplish these tasks. No P₄-ATPases have been identified in the endoplasmic reticulum and it remains an intriguing possibility that, in this compartment, P₅A-ATPases are functional homologues of P₄-ATPases. Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. Most importantly, biochemical characterization of P(4)-ATPases is required in order to clarify whether these transporters indeed are capable of catalyzing transmembrane phospholipid flipping. The beta-subunit of P(4)-ATPases shows unexpected similarities between the beta- and gamma-subunits of the Na+/K+-ATPase. It is likely that these proteins provide a similar solution to similar problems, and might have adopted similar structures to accomplish these tasks. No P(4)-ATPases have been identified in the endoplasmic reticulum and it remains an intriguing possibility that, in this compartment, P(5A)-ATPases are functional homologues of P(4)-ATPases. . Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. Most importantly, biochemical characterization of P 4 -ATPases is required in order to clarify whether these transporters indeed are capable of catalyzing transmembrane phospholipid flipping. The β-subunit of P 4 -ATPases shows unexpected similarities between the β- and γ-subunits of the Na + /K + -ATPase. It is likely that these proteins provide a similar solution to similar problems, and might have adopted similar structures to accomplish these tasks. No P 4 -ATPases have been identified in the endoplasmic reticulum and it remains an intriguing possibility that, in this compartment, P 5A -ATPases are functional homologues of P 4 -ATPases. Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. Most importantly, biochemical characterization of P4-ATPases is required in order to clarify whether these transporters indeed are capable of catalyzing transmembrane phospholipid flipping. The β-subunit of P4-ATPases shows unexpected similarities between the β- and γ-subunits of the Na+/K+-ATPase. It is likely that these proteins provide a similar solution to similar problems, and might have adopted similar structures to accomplish these tasks. No P4-ATPases have been identified in the endoplasmic reticulum and it remains an intriguing possibility that, in this compartment, P5A-ATPases are functional homologues of P4-ATPases. [PUBLICATION ABSTRACT] Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. Most importantly, biochemical characterization of P 4 -ATPases is required in order to clarify whether these transporters indeed are capable of catalyzing transmembrane phospholipid flipping. The β-subunit of P 4 -ATPases shows unexpected similarities between the β- and γ-subunits of the Na + /K + -ATPase. It is likely that these proteins provide a similar solution to similar problems, and might have adopted similar structures to accomplish these tasks. No P 4 -ATPases have been identified in the endoplasmic reticulum and it remains an intriguing possibility that, in this compartment, P 5A -ATPases are functional homologues of P 4 -ATPases. Our understandmg of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning to emerge. The results obtained so far demonstrate significant complexity within this field and point to major tasks for future research. Most importantly, biochemical characterization of P sub(4)-ATPases is required in order to clarify whether these transporters indeed are capable of catalyzing trans- membrane phospholipid flipping. The b-subunit of P sub(4)-ATPases shows unexpected similarities between the b- and g-subunits of the Na super(+)/K super(+)-ATPase. It is likely that these proteins provide a similar solution to similar problems, and might have adopted similar structures to accomplish these tasks. No P sub(4)-ATPases have been identified in the endoplasmic reticulum and it remains an intriguing possibility that, in this compartment, P sub(5A)-ATPases are functional homoloeues of P sub(4)-ATPases. |
| Author | Poulsen, L. R López-Marqués, R. L Palmgren, M. G |
| Author_xml | – sequence: 1 fullname: Poulsen, L. R – sequence: 2 fullname: López-Marqués, R. L – sequence: 3 fullname: Palmgren, M. G |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18791845$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkk1P3DAQhq0KVFjoD-gFIg6cSDtjJ_7ggirEl4TUQ4vUm2WSyRKUtRd7l6r_vl6yAtoDnGxrnnnHr19P2IYPnhj7jPAFAdTXBACoSwBdalFhKT-wbaw4lAYUbqz3UvNfW2yS0n2Ga83lR7aFWhnUVb3Njs6Hfj53idJxkRb9MBSzEKl4WFI-BZ-KxZ3zhfPpN8W0yzY7NyT6tF532M352c_Ty_L6-8XV6bfrsqk0LEoJMk-uGgfSkLs11AlHXDVIVEnRGt7VJLjSnLfGNW2FHCQY17W1IAApxQ47GXXny9sZtQ35RXSDncd-5uIfG1xv_634_s5Ow6NFRIEGRFY4XCvE8OTFzvrU0DA4T2GZrDSyRiHVuyAaWXGlMIMH_4H3YRl9fgbLUdRgFF9BOEJNDClF6p7vjGBXkdkxMpsjs6vI7Mrs3muzLx3rjDLARyDlkp9SfJn8lur-2NS5YN009sne_OCAIv-BGmsE8ReoRqs0 |
| CitedBy_id | crossref_primary_10_1002_iub_515 crossref_primary_10_1074_jbc_M109_013722 crossref_primary_10_1016_j_bbalip_2009_02_013 crossref_primary_10_1038_nrm2934 crossref_primary_10_1016_j_compbiolchem_2017_04_006 crossref_primary_10_1074_jbc_M112_387191 crossref_primary_10_1093_plphys_kiaa065 crossref_primary_10_1186_s12862_022_02071_0 crossref_primary_10_1371_journal_pone_0085139 crossref_primary_10_1371_journal_pone_0062577 crossref_primary_10_3389_fnmol_2014_00048 crossref_primary_10_1016_j_bbabio_2010_04_010 crossref_primary_10_1021_jm100086u crossref_primary_10_1134_S1068162015010070 crossref_primary_10_1371_journal_pone_0049027 crossref_primary_10_1016_j_cytogfr_2023_06_004 crossref_primary_10_1016_j_bbalip_2011_04_015 crossref_primary_10_1016_j_bbamem_2010_11_013 crossref_primary_10_1016_j_febslet_2010_04_071 crossref_primary_10_1038_s41477_021_00993_z crossref_primary_10_1016_j_plipres_2013_06_004 crossref_primary_10_1074_jbc_O114_555565 crossref_primary_10_1146_annurev_biophys_093008_131331 crossref_primary_10_1016_j_sbi_2010_06_007 crossref_primary_10_1208_s12249_019_1497_6 crossref_primary_10_1091_mbc_e09_08_0656 crossref_primary_10_1128_mBio_02694_20 crossref_primary_10_7124_bc_000029 crossref_primary_10_1111_j_1600_0854_2010_01079_x crossref_primary_10_1371_journal_pone_0027843 crossref_primary_10_1016_j_jbc_2023_105352 crossref_primary_10_1016_j_bbalip_2009_02_005 crossref_primary_10_3390_ijms14047897 crossref_primary_10_1242_jcs_114454 crossref_primary_10_1007_s10895_011_0933_0 crossref_primary_10_1016_j_bbagen_2014_04_008 crossref_primary_10_1242_jcs_088716 crossref_primary_10_3390_molecules181113666 crossref_primary_10_1134_S0026893318040167 crossref_primary_10_1016_j_febslet_2009_12_049 crossref_primary_10_1002_cyto_a_22886 crossref_primary_10_1007_s00424_013_1363_4 crossref_primary_10_1016_j_bbagen_2014_05_008 crossref_primary_10_1042_BCJ20200249 crossref_primary_10_1074_jbc_M112_371088 |
| ContentType | Journal Article |
| Copyright | Birkhaueser 2008 |
| Copyright_xml | – notice: Birkhaueser 2008 |
| DBID | FBQ CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QL 7QP 7QR 7SS 7T5 7T7 7TK 7TM 7TO 7U7 7U9 7X2 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA ATCPS AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0K M0S M1P M2O M7N M7P MBDVC P64 PATMY PQEST PQQKQ PQUKI PYCSY Q9U RC3 7X8 5PM |
| DOI | 10.1007/s00018-008-8341-6 |
| DatabaseName | AGRIS Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Toxicology Abstracts Virology and AIDS Abstracts Agricultural Science Collection ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest_Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts Environmental Science Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Environmental Science Collection ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Natural Science Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Technology Research Database ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Central Basic Toxicology Abstracts ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic Genetics Abstracts |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Biology |
| EISSN | 1420-9071 |
| EndPage | 3125 |
| ExternalDocumentID | 1896391651 10_1007_s00018_008_8341_6 18791845 US201301551510 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GroupedDBID | --- -56 -5G -BR -EM -Y2 -~C -~X .55 .86 .GJ .VR 06C 06D 0R~ 0VY 199 1N0 2.D 203 29B 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 36B 3O- 3SX 3V. 4.4 406 408 409 40D 40E 53G 5GY 5RE 5VS 67N 67Z 6NX 78A 7X2 7X7 7XC 88A 88E 8AO 8CJ 8FE 8FH 8FI 8FJ 8G5 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AABYN AAFGU AAHNG AAIAL AAJKR AANXM AANZL AARHV AARTL AATNV AATVU AAUYE AAWCG AAYFA AAYIU AAYQN AAYTO ABBBX ABBXA ABDZT ABECU ABELW ABFGW ABFTV ABHLI ABHQN ABJNI ABJOX ABKAS ABKCH ABKTR ABLJU ABMNI ABMQK ABNWP ABOCM ABPLI ABPTK ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACBMV ACBRV ACBXY ACBYP ACGFS ACHSB ACHVE ACHXU ACIGE ACIPQ ACIWK ACKNC ACMDZ ACMLO ACNCT ACOKC ACOMO ACPRK ACTTH ACVWB ACWMK ADBBV ADHIR ADIMF ADINQ ADKNI ADKPE ADMDM ADOAH ADOXG ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEEQQ AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AENEX AEOHA AEPYU AEQTP AESKC AESTI AETLH AEVLU AEVTX AEXYK AFEXP AFGCZ AFKRA AFLOW AFNRJ AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGMZJ AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AOCGG AOSHJ APEBS ARMRJ ASPBG ATCPS AVWKF AXYYD AZFZN AZQEC B-. BA0 BBNVY BDATZ BENPR BGNMA BHPHI BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP D1J D1K DDRTE DL5 DNIVK DPUIP DWQXO EBD EBLON EBS EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG F5P FBQ FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 GQ8 GUQSH GXS HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ K6- KDC KOV KPH LAS LK5 LK8 LLZTM M0K M0L M1P M2O M4Y M7P M7R MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM P19 P2P PATMY PF0 PQQKQ PROAC PSQYO PT4 PT5 PYCSY Q2X QOR QOS R89 R9I RNI RNS ROL RPX RRX RSV RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TSG TSK TSV TUC TWZ U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK8 X7M YLTOR Z45 Z7U Z7V Z7W Z7X Z7Y Z81 Z82 Z83 Z87 Z88 Z8O Z8P Z8Q Z8R Z8S Z8V Z8W Z91 ZGI ZMTXR ZOVNA ~02 ~KM AAEOY AAHBH AAKKN AAQLM AAYZH ABAKF ABEEZ ACACY ACULB ACZOJ AEFQL AFBBN AFGXO AGQEE AGRTI ALIPV C24 C6C CGR CUY CVF ECM EIF H13 NPM RPM AAYXX CITATION 7QL 7QP 7QR 7SS 7T5 7T7 7TK 7TM 7TO 7U7 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PQEST PQUKI Q9U RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c480t-6061424ca069eab9ef3ae27c1ee463d92f5e327822d9acd4120609afd53e00663 |
| IEDL.DBID | RPM |
| ISSN | 1420-682X |
| IngestDate | Tue Sep 17 21:28:14 EDT 2024 Sat Oct 26 05:11:24 EDT 2024 Fri Oct 25 09:18:24 EDT 2024 Tue Nov 19 05:08:17 EST 2024 Fri Nov 22 00:16:31 EST 2024 Sat Nov 02 12:31:18 EDT 2024 Sat Dec 16 12:04:55 EST 2023 Wed Dec 27 19:18:56 EST 2023 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 20 |
| Keywords | P Flippases vesicle formation phospholipid flipping ATPases |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c480t-6061424ca069eab9ef3ae27c1ee463d92f5e327822d9acd4120609afd53e00663 |
| Notes | http://dx.doi.org/10.1007/s00018-008-8341-6 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| PMID | 18791845 |
| PQID | 213509721 |
| PQPubID | 54068 |
| PageCount | 7 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_11131903 proquest_miscellaneous_69651367 proquest_miscellaneous_19642771 proquest_journals_213509721 crossref_primary_10_1007_s00018_008_8341_6 pubmed_primary_18791845 springer_journals_10_1007_s00018_008_8341_6 fao_agris_US201301551510 |
| PublicationCentury | 2000 |
| PublicationDate | 2008-10-01 |
| PublicationDateYYYYMMDD | 2008-10-01 |
| PublicationDate_xml | – month: 10 year: 2008 text: 2008-10-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Basel |
| PublicationPlace_xml | – name: Basel – name: Switzerland |
| PublicationTitle | Cellular and molecular life sciences : CMLS |
| PublicationTitleAbbrev | Cell. Mol. Life Sci |
| PublicationTitleAlternate | Cell Mol Life Sci |
| PublicationYear | 2008 |
| Publisher | Basel : SP Birkhäuser Verlag Basel Birkhäuser-Verlag Springer Nature B.V |
| Publisher_xml | – name: Basel : SP Birkhäuser Verlag Basel – name: Birkhäuser-Verlag – name: Springer Nature B.V |
| SSID | ssj0015826 |
| Score | 2.2116992 |
| SecondaryResourceType | review_article |
| Snippet | Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just... . Our understanding of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just... Our understandmg of flippase-mediated lipid translocation and membrane vesiculation, and the involvement of P-type ATPases in these processes is just beginning... |
| SourceID | pubmedcentral proquest crossref pubmed springer fao |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 3119 |
| SubjectTerms | Adenosine Triphosphatases - metabolism Amino Acid Sequence Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cellular biology Enzymes Eukaryotes Humans Life Sciences Lipid Bilayers - metabolism Lipids Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Molecular Sequence Data Phospholipid Transfer Proteins - chemistry Phospholipid Transfer Proteins - metabolism Phospholipids - metabolism Protein Transport Translocation Visions & Reflections (Minireview) |
| SummonAdditionalLinks | – databaseName: SpringerLINK Complete - EKUAL dbid: AEJHL link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NT9swFH-ioElc-OhgDV_LYYcNCEqcxLF3Q9CqmhCXDomb5cQuVKvSirSH_fd7L1-oG0OCSxTJluWP9_3s3wP4YhMptfU1BaokfgzKwQz_gowqb2uTifIy5nCU3N6L6z7B5LA2dJH_umgykqWgbt-6kTUiPMrWC5S8Hu_ABqqeGGl747L_Y3jT5g5iwao3ReQYCXbf5DJfGmRFG3XGevaSofnvfcm_kqalLhpsv2cVO7BVW57uZUUqu7Bm8y58qGpR_u7Cbs3lhfu1hqL-9hHOB9PJfI6KrvjuoiyYTl26l-uWEyd6dSnw7qK2o1Jre3A36P-8Gnp1fQUvi4S_8Dh5gyzKtM-l1am041BblmSBtREPjWTj2IaMTAgjdWaigPncl3ps4tCWpso-rOez3PbAzVLCHUPP1vAkMiZJceRUSBuj_Zn6gXHgtNlnNa9gNFQLmFzuiaJymLQnijvQw5NQ-gHFnLobMUqukmWH4sOBw-Z4VM1shWJBGJcoRA58bluRSyj1oXM7WxaKYMdYkrzSg0seE3ydA5-qw36ep0gk-sGxA2KFDNoOhNC92pJPHkukblQkKOL80IGzhhyep_3f9R-8qfchbLIGozc4gvXF09IeQ6cwy5OaM_4A_CYDfg priority: 102 providerName: Springer Nature |
| Title | Flippases: still more questions than answers |
| URI | https://link.springer.com/article/10.1007/s00018-008-8341-6 https://www.ncbi.nlm.nih.gov/pubmed/18791845 https://www.proquest.com/docview/213509721 https://search.proquest.com/docview/19642771 https://www.proquest.com/docview/69651367 https://pubmed.ncbi.nlm.nih.gov/PMC11131903 |
| Volume | 65 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDCaWDgN2GdbuUbdb58MOe7mxZVuWduu6BNmwFQW6Ar0JsqR0AVInqJvD_v1I2UqRvQ672AYk2DJFiqRIfQR46SoptUs1bVRJvFhcBw0-ZYYqb2trhE_GnJxVJxfi44hgcng4C-OT9k09O2zmV4fN7LvPrVxemWHIExuefj2m8uioyPLhAAZoHAYfvY8dlIJ1Z4rIMRLsIsQyUw8dmmYioZC_wOU78QWMRCXRzSk3FNNgqhd_sjl_T538JX7q1dL4ITzo7cn4qBv3NtxxzQ7c6ypM_tiB7V522_hVDzD9-hG8G89nyyWqr_Z9jBI-n8eUbRv7MRAXxrSdHqMOowJqj-F8PPp2PEn6qgmJKUR6k3Dy8VhhdMql07V001w7VpnMuYLnVrJp6XJGhoGV2tgiYylPpZ7aMnfeAHkCW82icbsQm5rQxNBftbwqrK1qfHMtpCvRqqzTzEbwJpBMLTtwDLWGQfakVlTkkkiteAS7SFSlL3HxUudnjEKmZK_hohDBfqC06kWoVSzLS48tFMGLdSvyPgU0dOMWq1YRmBirqn_04JKXBEoXwdNu3m7H2U97BGJjRtcdCHd7swXZ0eNvB_aL4G2Y_Nth__X_9_7_Q_twnwUY3uwZbN1cr9xzGLR2dQB3j0afJ1_wPv508uH0wIvCT6BQBAw |
| link.rule.ids | 230,315,729,782,786,887,27933,27934,41073,42142,48344,48347,48357,49649,49652,49662,52153,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB51QQgutFAeKRRy6AFaIiVO4ti9IcqyqJQLi8TNcmIvrLTKrhr20H_PjPNA20Kl9hJFsmX5MU_P-BuATzaTUttQ00WVxI9BOVjgX1RQ5W1tCuGSMQc32fWd-HZOMDlx-xbGZbu3IUknqbvHbmSOiIDC9QJFb8B7sJxIniApL59eDi_6XfAgFax-VESekWB3bTDzpUEW1FFvpKcvWZp_Jkz-FjV1yqj_9r-W8Q7WG9vTP62JZQPe2HITVupqlL82YaPh88o_asCoj9_DSX8yns1Q1VVffZQGk4lPmbm-mzlRrE9X7z7qOyq2tgW3_fPh2SBoKiwERSLCx4CTP8iSQodcWp1LO4q1ZVkRWZvw2Eg2Sm3MyIgwUhcmiVjIQ6lHJo2tM1a2YamclnYX_CIn5DH0bQ3PEmOyHEfOhbQpWqB5GBkPPrcbrWY1kIbqIJPdnigqiEl7orgHu3gUSt-joFO3N4zCq2TboQDxYK89H9WwW6VYFKcOh8iDw64V-YSCH7q003mlCHiMZdlfenDJUwKw82CnPu3neYpMoieceiAW6KDrQBjdiy3l-MFhdaMqQSEXxh58acnhedqvrv_DP_U-hNXB8MeVurq8_r4Ha6xF7I32Yenx59x-hF5l5gcNmzwBlh8Hbg |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB51QUVcaHmnUMihhz6ISJzEsbkgVHa1bRGqBEjcLCd2AGmVXZHdA_-embzQtlCp4hJFsmX5MU-P5xuATzaRUltf00WVxI9BOZjhX5BR5W1tMlE9xhxeJOfX4rRPMDnHbS5M9dq9DUnWOQ2E0lRMDycmP-wS38g0ER6F7gWKYY_3YDFCRwYJffGk_3N41gUSYsHqBCPykgS7bgObzw0yp5p6uR4_Z3X-_XjyjwhqpZgG7169pPew0tik7klNRKvwxhZr8LauUvmwBqsN_5fu5wak-ss6HAxGd5MJqsDyyEUpMRq59GLXrVZBlOzSlbyLepCKsG3A1aB_-X3oNZUXvCwS_tTj5CeyKNM-l1an0uahtizJAmsjHhrJ8tiGjIwLI3VmooD53Jc6N3FoKyNmExaKcWG3wc1SQiRDn9fwJDImSXHkVEgbo2Wa-oFx4Gu76WpSA2yoDkq52hNFhTJpTxR3YBuPRekbFIDq6oJR2JVsPhQsDuy0Z6UaNiwVC8K4widyYL9rRf6hoIgu7HhWKgIkY0nyjx5c8piA7RzYqk_-aZ4ikeghxw6IOZroOhB293xLcXdbYXijikHh54cOfGtJ42naL67_w3_13oel36cDdfbj_NcOLLMWyDfYhYXp_cx-hF5pZnsNxzwCBZEQMQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Flippases%3A+still+more+questions+than+answers&rft.jtitle=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.au=Poulsen%2C+L.+R.&rft.au=L%C3%B3pez-Marqu%C3%A9s%2C+R.+L.&rft.au=Palmgren%2C+M.+G.&rft.date=2008-10-01&rft.pub=Birkh%C3%A4user-Verlag&rft.issn=1420-682X&rft.eissn=1420-9071&rft.volume=65&rft.issue=20&rft_id=info:doi/10.1007%2Fs00018-008-8341-6&rft.externalDocID=10_1007_s00018_008_8341_6 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1420-682X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1420-682X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1420-682X&client=summon |