Clinical and EEG features of acute intrathecal baclofen overdose

• Published in: Clinical neurology and neurosurgery Vol. 114; no. 1; pp. 84 - 86
• Main Authors: Sauneuf, Bertrand, Totouom, Hervé Kamga, Savary, Benoit, Varin, Laurent, Dupeyrat, Julien, Ramakers, Sophie, Hanouz, Jean-Luc
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-01-2012; Elsevier; Elsevier Limited
• Subjects: Acute respiratory failure; Baclofen; Baclofen - administration & dosage; Baclofen - adverse effects; Baclofen - cerebrospinal fluid; Biological and medical sciences; Drug Overdose; Drug therapy; Electroencephalography; Electroencephalography - drug effects; Ependymoma - surgery; Equipment Failure; GABA Agonists - administration & dosage; GABA Agonists - adverse effects; GABA Agonists - cerebrospinal fluid; Glasgow Coma Scale; Humans; Implantable pump; Infusion Pumps, Implantable; Injections, Spinal; Intensive care; Intrathecal overdose; Male; Medical sciences; Middle Aged; Muscle Relaxants, Central - administration & dosage; Muscle Relaxants, Central - adverse effects; Muscle Relaxants, Central - cerebrospinal fluid; Neurology; Neurosurgery; Quadriplegia - etiology; Respiratory Distress Syndrome, Adult - etiology; Spinal Neoplasms - surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Acute respiratory failure; Intrathecal overdose; Implantable pump; Baclofen; Nervous system diseases; Surgery; Overdosing; Electroencephalography; Acute respiratory insufficiency; Intrathecal
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2011.07.028

[...]we estimated that the patient received 55mg baclofen intrathecally. The hypothesis is that blocking the presynaptic release of neurotransmitters would lead to a suppression of inhibition, through an effect on inhibitory interneurons, resulting in cellular polarization responsible for seizures [10]. [...]while baclofen may have antiepileptic properties at low doses, high doses lead to a net excitatory effect.