Magnetic fluid hyperthermia: Focus on superparamagnetic iron oxide nanoparticles

• Published in: Advances in colloid and interface science Vol. 166; no. 1; pp. 8 - 23
• Main Authors: Laurent, Sophie, Dutz, Silvio, Häfeli, Urs O., Mahmoudi, Morteza
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 10-08-2011; Elsevier
• Subjects: Animals; Cancer; Chemical Phenomena; Chemistry; Colloidal state and disperse state; Communities; Control systems; Drug Delivery Systems; Exact sciences and technology; General and physical chemistry; Humans; Hyperthermia; Hyperthermia, Induced - methods; Iron oxides; Magnetic fluids; Magnetic properties; Magnetics; Magnetite Nanoparticles - chemistry; Magnetite Nanoparticles - therapeutic use; Materials Testing; Nanoparticles; Physical and chemical studies. Granulometry. Electrokinetic phenomena; Physiochemical properties; Superparamagnetic iron oxide nanoparticles; Temperature; Theragnostics; Theragnostics; Physiochemical properties; Superparamagnetic iron oxide nanoparticles; Hyperthermia; Cancer; Drug; Iron oxide; Nanoparticle; Transition element compounds; Superparamagnetism; Review; Magnetic fluid; Potential; Biocompatibility; Magnetic properties
• ISSN: 0001-8686; 1873-3727
• DOI: 10.1016/j.cis.2011.04.003

Due to their unique magnetic properties, excellent biocompatibility as well as multi-purpose biomedical potential (e.g., applications in cancer therapy and general drug delivery), superparamagnetic iron oxide nanoparticles (SPIONs) are attracting increasing attention in both pharmaceutical and industrial communities. The precise control of the physiochemical properties of these magnetic systems is crucial for hyperthermia applications, as the induced heat is highly dependent on these properties. In this review, the limitations and recent advances in the development of superparamagnetic iron oxide nanoparticles for hyperthermia are presented.
Magnetic fluid hyperthermia has been developed through the testing of different superparamagnetic nanoparticles in vitro and in vivo, and has now reached the stage of clinical trials for the treatment of many different cancer types.
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► Size and surface modified SPIONs enable a safe and reproducible application to the tumor. ► SPIONs can be magnetically targeted and concentrated in the tumor tissue. ► Optimized SPIONs show a heating efficiency sufficient for a hyperthermia tumor therapy. ► Cancer specific binding agents on the SPIONs surface makes this therapy very selective. ► First clinical trials with SPION hyperthermia were carried out and showed promising results.