Bioderived Polyelectrolyte Nanogels for Robust Antigen Loading and Vaccine Adjuvant Effects
An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into ant...
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| Published in: | Small (Weinheim an der Bergstrasse, Germany) Vol. 7; no. 23; pp. 3281 - 3286 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Weinheim
WILEY-VCH Verlag
02-12-2011
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
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| Abstract | An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen‐presenting cells and strongly induce ovalbumin‐specific INF‐γ producing cells, cytotoxic T cell activity, and antibody production. |
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| AbstractList | An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF- gamma producing cells, cytotoxic T cell activity, and antibody production. An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen‐presenting cells and strongly induce ovalbumin‐specific INF‐γ producing cells, cytotoxic T cell activity, and antibody production. |
| Author | Lim, Yong Taik Lee, Kyung-Soon Poo, Haryoung Bae, Hee Ho Uyama, Hiroshi Sung, Moon-Hee Hong, Kwan Soo Shim, Sang-Mu Noh, Young-Woock Choi, Doo-Yeol Kim, Ji Hyun |
| Author_xml | – sequence: 1 givenname: Yong Taik surname: Lim fullname: Lim, Yong Taik organization: Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, South Korea – sequence: 2 givenname: Sang-Mu surname: Shim fullname: Shim, Sang-Mu organization: Viral Infectious Disease Research Centre, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, South Korea – sequence: 3 givenname: Young-Woock surname: Noh fullname: Noh, Young-Woock organization: Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, South Korea – sequence: 4 givenname: Kyung-Soon surname: Lee fullname: Lee, Kyung-Soon organization: Viral Infectious Disease Research Centre, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, South Korea – sequence: 5 givenname: Doo-Yeol surname: Choi fullname: Choi, Doo-Yeol organization: Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul and BioLeaders Corporation, Daejeon 305-500, South Korea – sequence: 6 givenname: Hiroshi surname: Uyama fullname: Uyama, Hiroshi organization: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka 565-0871, Japan – sequence: 7 givenname: Hee Ho surname: Bae fullname: Bae, Hee Ho organization: Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, South Korea – sequence: 8 givenname: Ji Hyun surname: Kim fullname: Kim, Ji Hyun organization: Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, South Korea – sequence: 9 givenname: Kwan Soo surname: Hong fullname: Hong, Kwan Soo organization: Korea Basic Science and Institute, Ochang, Chungbuk 368-883, South Korea – sequence: 10 givenname: Moon-Hee surname: Sung fullname: Sung, Moon-Hee email: smoonhee@kookmin.ac.kr organization: Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul and BioLeaders Corporation, Daejeon 305-500, South Korea – sequence: 11 givenname: Haryoung surname: Poo fullname: Poo, Haryoung email: haryoung@kribb.re.kr organization: Viral Infectious Disease Research Centre, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, South Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22009658$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adjuvants Adjuvants, Immunologic - pharmacology Animals Antibodies Antigen Presentation - drug effects Antigens Antigens - immunology Biocompatible Materials - pharmacology Bone Marrow Cells - cytology Bone Marrow Cells - drug effects dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects drug delivery Electrolytes - pharmacology Immunity, Cellular - drug effects Immunity, Humoral - drug effects Mice Microscopy, Electron, Scanning Microscopy, Fluorescence Nanostructure Nanotechnology Ovalbumin - immunology Particle Size polyelectrolyte nanogels Polyelectrolytes Polyethylene Glycols - pharmacology Polyethyleneimine - pharmacology Static Electricity Strategy T cell receptors Uptakes vaccine adjuvant Vaccines Vaccines - immunology |
| Title | Bioderived Polyelectrolyte Nanogels for Robust Antigen Loading and Vaccine Adjuvant Effects |
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