Bioderived Polyelectrolyte Nanogels for Robust Antigen Loading and Vaccine Adjuvant Effects

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 7; no. 23; pp. 3281 - 3286
• Main Authors: Lim, Yong Taik, Shim, Sang-Mu, Noh, Young-Woock, Lee, Kyung-Soon, Choi, Doo-Yeol, Uyama, Hiroshi, Bae, Hee Ho, Kim, Ji Hyun, Hong, Kwan Soo, Sung, Moon-Hee, Poo, Haryoung
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 02-12-2011; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Adjuvants; Adjuvants, Immunologic - pharmacology; Animals; Antibodies; Antigen Presentation - drug effects; Antigens; Antigens - immunology; Biocompatible Materials - pharmacology; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; dendritic cells; Dendritic Cells - cytology; Dendritic Cells - drug effects; drug delivery; Electrolytes - pharmacology; Immunity, Cellular - drug effects; Immunity, Humoral - drug effects; Mice; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Nanostructure; Nanotechnology; Ovalbumin - immunology; Particle Size; polyelectrolyte nanogels; Polyelectrolytes; Polyethylene Glycols - pharmacology; Polyethyleneimine - pharmacology; Static Electricity; Strategy; T cell receptors; Uptakes; vaccine adjuvant; Vaccines; Vaccines - immunology
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201101836

An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen‐presenting cells and strongly induce ovalbumin‐specific INF‐γ producing cells, cytotoxic T cell activity, and antibody production.