Development of liver microtissues with functional biliary ductular network

Liver tissue engineering aims to create transplantable liver grafts that can serve as substitutes for donor's livers. One major challenge in creating a fully functional liver tissue has been to recreate the biliary drainage in an engineered liver construct through integration of bile canaliculi...

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Bibliographic Details
Published in:	Biotechnology and bioengineering Vol. 118; no. 1; pp. 17 - 29
Main Authors:	Hafiz, Ehab O. A., Bulutoglu, Beyza, Mansy, Soheir S., Chen, Yibin, Abu‐Taleb, Hoda, Soliman, Somia A. M., El‐Hindawi, Ali A. F., Yarmush, Martin L., Uygun, Basak E.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-01-2021
Subjects:	Animals Bile ducts Bile Ducts - cytology Bile Ducts - metabolism biliary ductular network Cells, Cultured cholangiocytes Duodenum Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Liver liver tissue engineering Liver transplantation Microcysts Rats Spheroids Spheroids, Cellular - cytology Spheroids, Cellular - metabolism Stromal cells Tight junctions Tissue Engineering Wound drainage biliary ductular network cholangiocytes spheroids liver tissue engineering hepatocytes
Online Access:	Get full text
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