EFFECT OF ETHAMIVAN (VANILLIC ACID DIETHYLAMIDE) ON THE RESPIRATORY RESPONSE OF HEALTHY YOUNG MEN TO CARBON DIOXIDE, IN THE ABSENCE OF HYPOXIA

EFFECT OF ETHAMIVAN (VANILLIC ACID DIETHYLAMIDE) ON THE RESPIRATORY RESPONSE OF HEALTHY YOUNG MEN TO CARBON DIOXIDE, IN THE ABSENCE OF HYPOXIA

The effect of ethamivan (vanillic acid diethylamide) on the ventilatory response to carbon dioxide has been investigated in healthy young adult males. Intravenous infusion of the drug at a rate of 9 mg/min causes respiratory stimulation depending in degree upon the prevailing alveolar CO2 tension. W...

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Bibliographic Details
Published in:British Journal of Pharmacology and Chemotherapy Vol. 19; no. 1; pp. 142 - 152
Main Authors: ANDERTON, J. L., COWIE, J. F., HARRIS, E. A., SLEET, R. A.
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-08-1962
Subjects:
Adult
Benzamides
Carbon Dioxide - pharmacology
Cell Respiration
Central Nervous System Stimulants - pharmacology
Humans
Hypoxia
Male
Old Medline
Respiration - pharmacology
Vanillic Acid
ANALEPTICS/pharmacology
CARBON DIOXIDE/pharmacology
RESPIRATION/pharmacology
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Summary:The effect of ethamivan (vanillic acid diethylamide) on the ventilatory response to carbon dioxide has been investigated in healthy young adult males. Intravenous infusion of the drug at a rate of 9 mg/min causes respiratory stimulation depending in degree upon the prevailing alveolar CO2 tension. When the latter is low stimulation by the drug is most marked and may largely support respiration below the CO2 threshold. As alveolar Pco2 increases, the effect of the drug disappears. These findings are discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0366-0826
1476-5381
DOI:10.1111/j.1476-5381.1962.tb01435.x