The Impact of Highly Active Antiretroviral Therapy and Immunodeficiency on Human Papillomavirus Infection of the Oral Cavity of Human Immunodeficiency Virus-Seropositive Adults

• Published in: Sexually transmitted diseases Vol. 32; no. 11; pp. 703 - 709
• Main Authors: CAMERON, JENNIFER E., MERCANTE, DONALD, O'BRIEN, MEGAN, GAFFGA, ANN M., LEIGH, JANET E., FIDEL, PAUL L., HAGENSEE, MICHAEL E.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01-11-2005; Lippincott; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adult; African Americans; Antiretroviral Therapy, Highly Active; Biological and medical sciences; Black or African American; Black People; DNA, Viral - analysis; DNA, Viral - isolation & purification; Drug therapy; Female; General aspects; HIV; HIV Seropositivity - complications; HIV Seropositivity - drug therapy; HIV Seropositivity - immunology; Human immunodeficiency virus; Human infectious diseases. Experimental studies and models; Human papillomavirus; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Middle Aged; Mouth Diseases - complications; Mouth Diseases - drug therapy; Mouth Diseases - epidemiology; Mouth Neoplasms - complications; Mouth Neoplasms - drug therapy; Mouth Neoplasms - epidemiology; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - complications; Papillomavirus Infections - drug therapy; Papillomavirus Infections - epidemiology; Papillomavirus Infections - immunology; Risk Factors; Saliva - virology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Warts - complications; Warts - drug therapy; Warts - epidemiology; White People; Human; Immunopathology; Antiretroviral agent; Seropositivity; Stomatology; Retroviridae; AIDS; Papovaviridae; Lentivirus; Epidemiology; Immune deficiency; Papillomavirus; Virus; Infection; Oral cavity; Human papillomavirus; Sexually transmitted disease; Treatment; Viral disease; Risk factor; Adult; Antiviral; Human immunodeficiency virus; Public health
• ISSN: 0148-5717; 1537-4521
• DOI: 10.1097/01.olq.0000175398.34610.2e

Background: Prevalence of human papillomavirus (HPV)-associated oral condylomas has reportedly increased in HIV-infected individuals since the introduction of highly active antiretroviral therapy (HAART). The relationships between HIV therapy regimen, overall health, and subclinical oral HPV have not been examined. Goal: To determine oral HPV genotype prevalence and the impact of HAART and health in the HIV+ population. Study: An LI consensus-primer polymerase chain reaction and linear array assay were used to examine the prevalence of 27 HPV genotypes in saliva of 98 HIV+ individuals. Risk assessment variables were compared to oral HPV status. Results: Oral HPV was detected in 37% of HIV+ African American individuals. Caucasians were at greater risk of oral HPV infection than African Americans. Markers of advanced HIV disease did not predict HPV status. Therapy status was associated with HPV detection. Conclusions: Treatment of HIV, rather than HTV immunosuppression, appears to play a role in oral HPV infections in HTV+ individuals.