Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

• Published in: International journal of hyperthermia Vol. 36; no. 1; pp. 1146 - 1158
• Main Authors: Zhu, Lifei, Partanen, Ari, Talcott, Michael R., Gach, H. Michael, Greco, Suellen C., Henke, Lauren E., Contreras, Jessika A., Zoberi, Imran, Hallahan, Dennis E., Chen, Hong, Altman, Michael B.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01-01-2019; Taylor & Francis Group
• Subjects: Animals; Feasibility Studies; Fever; HIFU; High-Intensity Focused Ultrasound Ablation - methods; Humans; hyperthermia; image-guided therapy; Magnetic Resonance Imaging - methods; MR thermometry; MR-guided HIFU; Pelvis - pathology; Swine; HIFU; MR-guided HIFU; hyperthermia; MR thermometry; image-guided therapy
• ISSN: 0265-6736; 1464-5157
• DOI: 10.1080/02656736.2019.1685684

Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40-45 °C) in various pelvic targets in a porcine model in vivo.
Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology.
Results: Across all HT sessions, the mean difference between average temperature (T
avg
) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min T
avg
variation was 0.80 ± 0.17 °C, and the maximum difference between T
avg
and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis.
Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients.