The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats

• Published in: Behavioural brain research Vol. 205; no. 1; pp. 315 - 318
• Main Authors: Kawaura, Kazuaki, Ogata, Yukino, Inoue, Masako, Honda, Sokichi, Soeda, Fumio, Shirasaki, Tetsuya, Takahama, Kazuo
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 14-12-2009; Elsevier
• Subjects: Analysis of Variance; Animals; Antidepressant-like effect; Antidepressive Agents - administration & dosage; Antidepressive Agents - pharmacology; Antitussives; Behavioral psychophysiology; Biological and medical sciences; Depression - drug therapy; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Forced swimming test; Fundamental and applied biological sciences. Psychology; G-protein-coupled inwardly rectifying K + (GIRK) channel; Locomotion - drug effects; Male; Medical sciences; Motor Activity - drug effects; Neuropharmacology; Neuropsychological Tests; Pharmacology. Drug treatments; Piperidines - administration & dosage; Piperidines - pharmacology; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopharmacology; Rats; Rats, Wistar; Swimming; Time Factors; Tipepidine; Forced swimming test; Antidepressant-like effect; Antitussives; Dopamine; G-protein-coupled inwardly rectifying K + (GIRK) channel; Tipepidine; Rat; Illicit drug; Psychotropic; Rodentia; Antitussive agent; Catecholamine; Inorganic element; Stress; G-protein-coupled inwardly rectifying K; Vertebrata; Mammalia; Animal; Neurotransmitter; Antidepressant agent; Potassium; (GIRK)channel; G protein
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2009.07.004

The antidepressant-like effect of tipepidine was studied in rats. Tipepidine at 20 and 40
mg/kg i.p. reduced immobility in the forced swimming test and tipepidine at 40
mg/kg, i.p. increased climbing in the test. The drug at 40
mg/kg, i.p. had no effect on the locomotor activity and motor coordination. These results suggest that tipepidine may be a novel drug with antidepressant-like activity.