A Human Fibroblast-Derived Growth Factor Preparation in the Management of a Chronic Surgical Wound in a Diabetic Patient: A Case Report

A Human Fibroblast-Derived Growth Factor Preparation in the Management of a Chronic Surgical Wound in a Diabetic Patient: A Case Report

The treatment of choice in patients with ischaemic heart disease is coronary artery bypass grafting. The procedure entails the harvesting of the great saphenous vein through a significant leg incision, which may result in infections and wounding at the incision site. Patients with diabetes mellitus...

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Bibliographic Details
Published in:International medical case reports journal Vol. 14; pp. 551 - 556
Main Authors: Angelo-Khattar, Maria, Vadarli, Georgia
Format: Journal Article
Language:English
Published: Macclesfield Dove Medical Press Limited 31-08-2021
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects:
Cardiovascular disease
Care and treatment
Case Report
Case reports
chronic wound
Coronary artery bypass
coronary artery bypass graft
Coronary vessels
Cytokines
Debridement
Diabetes
Diabetics
Edema
Epidermal growth factor
Erythema
Fibroblasts
growth factors
Health aspects
Heart diseases
Heart surgery
Infections
Inflammation
Interleukins
Ischemia
Pain
Patients
Physiology
Scars
Type 2 diabetes
Veins & arteries
Wound healing
Wounds and injuries
United States > US
California
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Summary:The treatment of choice in patients with ischaemic heart disease is coronary artery bypass grafting. The procedure entails the harvesting of the great saphenous vein through a significant leg incision, which may result in infections and wounding at the incision site. Patients with diabetes mellitus pose a greater risk of developing non-healing wounds, which may significantly affect the patient's quality of life. The use of anti-inflammatory factors and other chemokines derived from cultured human fibroblasts may represent a useful therapeutic approach for the management of surgical wounds in patients with the greatest probability of being wound healing compromised. This case study describes the treatment of a non-healing surgical tibial wound in a male diabetic patient treated with a preparation of human anti-inflammatory interleukins cytokines, and growth factors. The treatment resulted in swift recovery, significant pain reduction and complete wound closure with minimal scarring. Keywords: chronic wound, growth factors, cytokines, coronary artery bypass graft
ISSN:1179-142X
1179-142X
DOI:10.2147/IMCRJ.S319531