Contractile properties of myocardium are altered in dystrophin-deficient mdx mice

The objective of this study was to determine whether cardiac contractile force is altered in the dystrophin-deficient mdx mouse model of muscular dystrophy. Left atria from 12-14-week-old control and mdx mice were paced at 1 Hz in 1.25 mM external Ca2+ buffer. Twitch properties and effects of interp...

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Bibliographic Details
Published in:	Journal of the neurological sciences Vol. 142; no. 1-2; pp. 17 - 24
Main Authors:	SAPP, J. L, BOBET, J, HOWLETT, S. E
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Science 01-10-1996
Subjects:	Animals Biological and medical sciences Calcium - metabolism Diseases of striated muscles. Neuromuscular diseases Dystrophin - genetics Female Heart - physiology Medical sciences Mice Mice, Inbred C57BL Mice, Inbred mdx - physiology Muscle Contraction - physiology Muscle Fibers, Skeletal - physiology Mutation - physiology Myocardium - chemistry Myocardium - metabolism Neurology Animal model Neuromuscular diseases Nervous system diseases Rodentia Contractility Exploration Genetic disease Vertebrata Mammalia Mouse Animal Duchenne muscular dystrophy Myocardium Dystrophin
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