Persistence of altered 5-hydroxytryptamine turnover following hemibody X-irradiation in the rat distal colon

Purpose: Acute gastrointestinal responses to ionizing radiation exposure include a role for 5-hydroxytryptamine (5-HT), but it is not known whether involvement of 5-HT persists and contributes to late effects. The aim was to investigate the acute and later effects of lower hemibody irradiation on 5-...

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Bibliographic Details
Published in:	International journal of radiation biology Vol. 80; no. 6; pp. 399 - 411
Main Authors:	Ropenga, A., Combes, O., Chapel, A., Griffiths, N. M.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 01-06-2004 Taylor & Francis
Subjects:	Animals Base Sequence Carrier Proteins - genetics Carrier Proteins - metabolism Cell Division - radiation effects Colon - drug effects Colon - metabolism Colon - pathology Colon - radiation effects DNA - genetics Enterochromaffin Cells - metabolism Enterochromaffin Cells - pathology Enterochromaffin Cells - radiation effects Evoked Potentials - drug effects Evoked Potentials - radiation effects Gene Expression - radiation effects Hydroxyindoleacetic Acid - blood Hydroxyindoleacetic Acid - metabolism Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - radiation effects Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Transport Proteins Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Rats Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Serotonin - blood Serotonin - metabolism Serotonin - pharmacology Serotonin Plasma Membrane Transport Proteins Space life sciences Time Factors Tryptophan Hydroxylase - genetics
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