Comparative effects of fractional radiofrequency and microneedling on the genitalia of postmenopausal women: Histological and clinical changes
•Radiofrequency is effective in flaccidity.•Radiofrequency provokes collagen remodeling. The authors aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar tissue. Thirty postmenopausal women were randomly divided into G1 (FRF) and...
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| Published in: | Clinics (São Paulo, Brazil) Vol. 77; p. 100117 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier España, S.L.U
01-01-2022
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Faculdade de Medicina / USP |
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| Abstract | •Radiofrequency is effective in flaccidity.•Radiofrequency provokes collagen remodeling.
The authors aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar tissue.
Thirty postmenopausal women were randomly divided into G1 (FRF) and G2 (microneedling) groups. Sub-ablative FRF was executed using disposable fractionated electrodes with an intensity of 8 mJ. Microneedling was performed using a derma roller system. The authors evaluated before and after treatment using the Vaginal Laxity Questionnaire (VLQ), EuroQol Five-Dimensional (EQ-5D) questionnaire, and the Blatt and Kupperman Menopausal Index (BKMI). Additionally, the authors performed biopsies of the labia majora for histological analysis pre- and post-treatment. Data were expressed as mean (± standard deviation). A paired t-test was used for intra-group comparison (pre- and post-treatment), with an independent t-test used to compare intergroup data (both pre- and post-treatment).
In the G1 group, the VLQ values showed differences compared to the pre-treatment values with the data obtained 60 days after the beginning of the sessions (p = 0.01). Similarly, the data changes of the G2 group proved to be significant (p = 0.001) across the same time interval. In comparing the groups, VLQ values were not different (p > 0.05). Regarding histological analysis, FRF demonstrated improvement concerning the number of fibroblasts, blood vessels, and fatty degeneration (p < 0.05) compared to the control. Additionally, FRF and microneedling samples showed higher type III collagen and vimentin expression in the immunohistochemical analysis (p < 0.05).
The therapies were found to be effective in treating the flaccidity of the female external genitalia. Additionally, histological changes were observed after interventions suggesting collagen remodeling. |
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| AbstractList | Abstract Objectives: The authors aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar tissue. Methods: Thirty postmenopausal women were randomly divided into G1 (FRF) and G2 (microneedling) groups. Sub-ablative FRF was executed using disposable fractionated electrodes with an intensity of 8 mJ. Microneedling was performed using a derma roller system. The authors evaluated before and after treatment using the Vaginal Laxity Questionnaire (VLQ), EuroQol Five-Dimensional (EQ-5D) questionnaire, and the Blatt and Kupperman Menopausal Index (BKMI). Additionally, the authors performed biopsies of the labia majora for histological analysis pre- and post-treatment. Data were expressed as mean (± standard deviation). A paired t-test was used for intra-group comparison (pre- and post-treatment), with an independent t-test used to compare intergroup data (both pre- and post-treatment). Results: In the G1 group, the VLQ values showed differences compared to the pre-treatment values with the data obtained 60 days after the beginning of the sessions (p = 0.01). Similarly, the data changes of the G2 group proved to be significant (p = 0.001) across the same time interval. In comparing the groups, VLQ values were not different (p > 0.05). Regarding histological analysis, FRF demonstrated improvement concerning the number of fibroblasts, blood vessels, and fatty degeneration (p < 0.05) compared to the control. Additionally, FRF and microneedling samples showed higher type III collagen and vimentin expression in the immunohistochemical analysis (p < 0.05). Conclusions: The therapies were found to be effective in treating the flaccidity of the female external genitalia. Additionally, histological changes were observed after interventions suggesting collagen remodeling. • Radiofrequency is effective in flaccidity. • Radiofrequency provokes collagen remodeling. •Radiofrequency is effective in flaccidity.•Radiofrequency provokes collagen remodeling. The authors aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar tissue. Thirty postmenopausal women were randomly divided into G1 (FRF) and G2 (microneedling) groups. Sub-ablative FRF was executed using disposable fractionated electrodes with an intensity of 8 mJ. Microneedling was performed using a derma roller system. The authors evaluated before and after treatment using the Vaginal Laxity Questionnaire (VLQ), EuroQol Five-Dimensional (EQ-5D) questionnaire, and the Blatt and Kupperman Menopausal Index (BKMI). Additionally, the authors performed biopsies of the labia majora for histological analysis pre- and post-treatment. Data were expressed as mean (± standard deviation). A paired t-test was used for intra-group comparison (pre- and post-treatment), with an independent t-test used to compare intergroup data (both pre- and post-treatment). In the G1 group, the VLQ values showed differences compared to the pre-treatment values with the data obtained 60 days after the beginning of the sessions (p = 0.01). Similarly, the data changes of the G2 group proved to be significant (p = 0.001) across the same time interval. In comparing the groups, VLQ values were not different (p > 0.05). Regarding histological analysis, FRF demonstrated improvement concerning the number of fibroblasts, blood vessels, and fatty degeneration (p < 0.05) compared to the control. Additionally, FRF and microneedling samples showed higher type III collagen and vimentin expression in the immunohistochemical analysis (p < 0.05). The therapies were found to be effective in treating the flaccidity of the female external genitalia. Additionally, histological changes were observed after interventions suggesting collagen remodeling. OBJECTIVESThe authors aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar tissue. METHODSThirty postmenopausal women were randomly divided into G1 (FRF) and G2 (microneedling) groups. Sub-ablative FRF was executed using disposable fractionated electrodes with an intensity of 8 mJ. Microneedling was performed using a derma roller system. The authors evaluated before and after treatment using the Vaginal Laxity Questionnaire (VLQ), EuroQol Five-Dimensional (EQ-5D) questionnaire, and the Blatt and Kupperman Menopausal Index (BKMI). Additionally, the authors performed biopsies of the labia majora for histological analysis pre- and post-treatment. Data were expressed as mean (± standard deviation). A paired t-test was used for intra-group comparison (pre- and post-treatment), with an independent t-test used to compare intergroup data (both pre- and post-treatment). RESULTSIn the G1 group, the VLQ values showed differences compared to the pre-treatment values with the data obtained 60 days after the beginning of the sessions (p = 0.01). Similarly, the data changes of the G2 group proved to be significant (p = 0.001) across the same time interval. In comparing the groups, VLQ values were not different (p > 0.05). Regarding histological analysis, FRF demonstrated improvement concerning the number of fibroblasts, blood vessels, and fatty degeneration (p < 0.05) compared to the control. Additionally, FRF and microneedling samples showed higher type III collagen and vimentin expression in the immunohistochemical analysis (p < 0.05). CONCLUSIONSThe therapies were found to be effective in treating the flaccidity of the female external genitalia. Additionally, histological changes were observed after interventions suggesting collagen remodeling. |
| ArticleNumber | 100117 |
| Author | Carreiro, Eneida de Morais Silva, Rodrigo Marcel Valentim da Farias, Stephany Luanna Queiroga Gonçalves, Ana Katherine Sarmento, Ayane Cristine Maia, Rafaella Rêgo Meyer, Patrícia Froes Soares, Ciro Dantas |
| AuthorAffiliation | Centro Universitário do Rio Grande do Norte (UNI-RN) Universidade Estácio de Sá Universidade Potiguar (UnP) Universidade Federal do Rio Grande do Norte Universidade Estadual de Campinas |
| AuthorAffiliation_xml | – name: Universidade Potiguar (UnP) – name: Centro Universitário do Rio Grande do Norte (UNI-RN) – name: Universidade Estácio de Sá – name: Universidade Federal do Rio Grande do Norte – name: Universidade Estadual de Campinas |
| Author_xml | – sequence: 1 givenname: Rafaella Rêgo orcidid: 0000-0001-7819-0690 surname: Maia fullname: Maia, Rafaella Rêgo organization: Health Sciences Postgraduate Program, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil – sequence: 2 givenname: Ayane Cristine orcidid: 0000-0001-9131-1952 surname: Sarmento fullname: Sarmento, Ayane Cristine organization: Health Sciences Postgraduate Program, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil – sequence: 3 givenname: Rodrigo Marcel Valentim da orcidid: 0000-0002-5859-4599 surname: Silva fullname: Silva, Rodrigo Marcel Valentim da organization: Physiotherapy Department, Centro Universitário do Rio Grande do Norte (UNI-RN), Natal, RN, Brazil – sequence: 4 givenname: Eneida de Morais orcidid: 0000-0003-3089-3690 surname: Carreiro fullname: Carreiro, Eneida de Morais organization: Physiotherapy Department, Centro Universitário do Rio Grande do Norte (UNI-RN), Natal, RN, Brazil – sequence: 5 givenname: Stephany Luanna Queiroga orcidid: 0000-0002-1988-4219 surname: Farias fullname: Farias, Stephany Luanna Queiroga organization: Physiotherapy Department, Universidade Potiguar (UnP), Natal, RN, Brazil – sequence: 6 givenname: Ciro Dantas orcidid: 0000-0002-6861-6640 surname: Soares fullname: Soares, Ciro Dantas organization: Tomatopathology Department, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil – sequence: 7 givenname: Patrícia Froes orcidid: 0000-0001-8530-8183 surname: Meyer fullname: Meyer, Patrícia Froes organization: Physiotherapy Department, Centro Universitário do Rio Grande do Norte (UNI-RN), Natal, RN, Brazil – sequence: 8 givenname: Ana Katherine orcidid: 0000-0002-8351-5119 surname: Gonçalves fullname: Gonçalves, Ana Katherine email: anakatherine_ufrnet@yahoo.com.br organization: Health Sciences Postgraduate Program, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil |
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| Keywords | Microneedling Radiofrequency Flaccidity Menopause |
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bib0012 article-title: Fractional CO2 laser treatment for vaginal atrophy and vulvar lichen sclerosus publication-title: J Gynecol Surg contributor: fullname: Baggish – volume: 76 start-page: e2567 year: 2021 ident: bib0013 article-title: Microablative fractional radiofrequency as a therapeutic option for vulvar lichen sclerosus: a pilot study publication-title: Clinics contributor: fullname: Baracat – volume: 16 start-page: 230 year: 2017 end-page: 234 ident: bib0034 article-title: Evaluation of the safety and efficacy of a monopolar nonablative radiofrequency device for the improvement of vulvo-vaginal laxity and urinary incontinence publication-title: J Cosmet Dermatol contributor: fullname: Lozanova – volume: 171 start-page: 1627 year: 1959 end-page: 1637 ident: bib0023 article-title: Contemporary therapy of the menopausal syndrome publication-title: J Am Med Assoc contributor: fullname: Blatt – volume: 27 start-page: 1681 year: 2016 end-page: 1687 ident: bib0006 article-title: 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| SSID | ssj0039345 |
| Score | 2.3242002 |
| Snippet | •Radiofrequency is effective in flaccidity.•Radiofrequency provokes collagen remodeling.
The authors aimed to evaluate clinical and histological changes... OBJECTIVESThe authors aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar tissue.... • Radiofrequency is effective in flaccidity. • Radiofrequency provokes collagen remodeling. Abstract Objectives: The authors aimed to evaluate clinical and histological changes induced by Fractional Radiofrequency (FRF) and microneedling in vulvar... |
| SourceID | scielo pubmedcentral proquest crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Publisher |
| StartPage | 100117 |
| SubjectTerms | Flaccidity MEDICINE, GENERAL & INTERNAL Menopause Microneedling Original Radiofrequency |
| Title | Comparative effects of fractional radiofrequency and microneedling on the genitalia of postmenopausal women: Histological and clinical changes |
| URI | https://dx.doi.org/10.1016/j.clinsp.2022.100117 https://search.proquest.com/docview/2720929894 https://pubmed.ncbi.nlm.nih.gov/PMC9529663 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322022000100281&lng=en&tlng=en |
| Volume | 77 |
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