Epidemiology of meningococcal disease in southern Brazil from 1995 to 2003, and molecular characterization of Neisseria meningitidis using multilocus sequence typing
To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State. The overall incidence fell by 50%; the case-fatality rate during this period was 22%. Even so, the incidence of MD...
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| Published in: | Tropical medicine & international health Vol. 13; no. 1; pp. 31 - 40 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
2008
Blackwell Publishing Ltd Blackwell Science |
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| Abstract | To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State. The overall incidence fell by 50%; the case-fatality rate during this period was 22%. Even so, the incidence of MD remained high after the epidemic period ended in 1999. Together, the age groups of 1-4 years and infants accounted for 54.1% of reported cases with incidences of 11.3/100 000 and 31.3/100 000, respectively; 69.8% of cases were caused by Neisseria meningitidis serogroup B, which increased significantly. There was a significant decrease in serogroup C cases in the whole period. The phenotypes B:4,7:P1.19,15, B:15:P1.7,16 and B:NT:P1.3 caused almost 50% of all serotyped cases. Fifty-six isolates obtained from RS patients during the first non-epidemic year 2000 plus 20 isolates from other southern Brazilian states (Santa Catarina and Paraná), Denmark and France were typed by multilocus sequence typing. Twenty sequence types (STs) were identified, eight of them found only in RS. ST-33 (27%) and ST-259 (18%) were the most frequent; both belong to the ST-32/ET-5 complex. ST-259 cases showed a trend towards higher risk of fatal outcome. ST-259 isolates were not detected among geographic controls or in other studies in Brazil. Our data suggest that ST-33 and ST-259 clones and the emergence of the ST-103 isolates contributed to the continued high incidence of MD in RS. |
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| AbstractList | OBJECTIVETo describe the epidemiology of meningococcal disease (MD) in southern Brazil.METHODSRetrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State.RESULTSThe overall incidence fell by 50%; the case-fatality rate during this period was 22%. Even so, the incidence of MD remained high after the epidemic period ended in 1999. Together, the age groups of 1-4 years and infants accounted for 54.1% of reported cases with incidences of 11.3/100 000 and 31.3/100 000, respectively; 69.8% of cases were caused by Neisseria meningitidis serogroup B, which increased significantly. There was a significant decrease in serogroup C cases in the whole period. The phenotypes B:4,7:P1.19,15, B:15:P1.7,16 and B:NT:P1.3 caused almost 50% of all serotyped cases. Fifty-six isolates obtained from RS patients during the first non-epidemic year 2000 plus 20 isolates from other southern Brazilian states (Santa Catarina and Paraná), Denmark and France were typed by multilocus sequence typing. Twenty sequence types (STs) were identified, eight of them found only in RS. ST-33 (27%) and ST-259 (18%) were the most frequent; both belong to the ST-32/ET-5 complex. ST-259 cases showed a trend towards higher risk of fatal outcome. ST-259 isolates were not detected among geographic controls or in other studies in Brazil.CONCLUSIONOur data suggest that ST-33 and ST-259 clones and the emergence of the ST-103 isolates contributed to the continued high incidence of MD in RS. Summary Objective To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Methods Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State. Results The overall incidence fell by 50%; the case‐fatality rate during this period was 22%. Even so, the incidence of MD remained high after the epidemic period ended in 1999. Together, the age groups of 1–4 years and infants accounted for 54.1% of reported cases with incidences of 11.3/100 000 and 31.3/100 000, respectively; 69.8% of cases were caused by Neisseria meningitidis serogroup B, which increased significantly. There was a significant decrease in serogroup C cases in the whole period. The phenotypes B:4,7:P1.19,15, B:15:P1.7,16 and B:NT:P1.3 caused almost 50% of all serotyped cases. Fifty‐six isolates obtained from RS patients during the first non‐epidemic year 2000 plus 20 isolates from other southern Brazilian states (Santa Catarina and Paraná), Denmark and France were typed by multilocus sequence typing. Twenty sequence types (STs) were identified, eight of them found only in RS. ST‐33 (27%) and ST‐259 (18%) were the most frequent; both belong to the ST‐32/ET‐5 complex. ST‐259 cases showed a trend towards higher risk of fatal outcome. ST‐259 isolates were not detected among geographic controls or in other studies in Brazil. Conclusion Our data suggest that ST‐33 and ST‐259 clones and the emergence of the ST‐103 isolates contributed to the continued high incidence of MD in RS. Épidémiologie de la maladie méningococcique dans le sud du Brésil de 1995 à 2003 et caractérisation moléculaire de Neisseria meningitidis en utilisant le typage de la séquence de multilocus Objectif: Décrire l’épidémiologie de la maladie méningococcique dans le sud du Brésil. Méthode: Etude de cohorte rétrospective sur 2215 cas de maladie méningococcique (MM) rapportés entre 1995 et 2003 dans l’état de Rio Grande do Sul (RS) au Brésil. Résultats: L’incidence globale a chuté de 50%. Le taux de cas fatals au cours de cette période était de 22%. Néanmoins, l’incidence de MM est demeurée élevée après la période épidémique finie en 1999. Au total, les groupes d’âge de 1 à 4 ans et les enfants en bas âge constituaient 54,1% des cas rapportés avec des incidences de 11,3/100000 et de 31,3/100000, respectivement. 69,8% des cas étaient causés par le sérogroupe B de Neisseria meningitidis, qui a augmenté de manière significative. Il y avait une diminution significative des cas dus au sérogroupe C dans toute la période. Les phénotypes B:4,7: P1.19,15, B:15:P1.7,16 et B:NT:P1.3 étaient responsables presque 50% de tous les cas sérotypés. 56 isolats obtenus à partir de patients de RS pendant la première année (2000) non épidémique et 20 isolats provenant d’autres états du sud du Brésil (Santa Catarina et Paraná), du Danemark et de France ont été typés par la typage de la séquence de multilocus. Vingt STs ont été identifiés, 8 d’entre eux ont été trouvés seulement à Rio Grande do Sul. ST‐33 (27%) et ST‐259 (18%) étaient les plus fréquents; tous les deux appartiennent au complexe ST‐32/ET‐5. Les cas ST‐259 indiquaientt une tendance vers un risque plus élevé de résultat mortel. Les isolats ST‐259 n’ont pas été détectés chez des contrôles géographiques ni dans d’autres études au Brésil. Conclusions: Nos données suggèrent que les clones ST‐33 et ST‐259 et l’émergence des isolats ST‐103 ont contribuéà l’incidence élevée continue de la maladie méningococcique à Rio Grande do Sul. Epidemiología de la Enfermedad Meningocócica al Sur de Brasil entre 1995 y 2003, y caracterización molecular Neisseria meningitidis mediante tipificación de la secuencia multilocus. Objetivo: Describir la epidemiología de la enfermedad meningocócica (EM) en el sur de Brasil. Método: Estudio de cohortes, entre 2,215 casos de enfermedad meningocócica reportados entre 1995 y 2003 en el estado de Rio Grande do Sul (RS), Brasil. Resultados: La incidencia total cayó en un 50%; la tasa de letalidad durante este periodo fue del 22%. Aún así, la incidencia de la EM se mantuvo alta después de que terminó el periodo epidémico en 1999. Los niños dentro del grupo de edad de 1–4 años y los bebes eran responsables del 54.1% de los casos reportados, con incidencias de 11.3/100000 y 31.3/100000, respectivamente. Un 69.8% de los casos era causado por Neisseria meningitidis serogrupo B, que aumentó significativamente. Hubo una disminución significativa en los casos de serogrupo C durante todo el periodo. Los fenotipos B:4,7:P1.19,15, B:15:P1.7,16 y B:NT:P1.3 causaron casi el 50% de todos los casos serotipados. 56 aislados obtenidos de pacientes de RS durante el 2000, primer año no epidémico, más 20 aislados de otros estados Brasileros (Santa Catarina y Paraná), Dinamarca y Francia fueron analizados mediante la Tipificación de la Secuencia Multilocus (ST). Se identificaron 20 STs, 8 de los cuales se encontraban solo en Rio Grande do Sul. ST‐33 (27%) y ST‐259 (18%) eran los más frecuentes; ambos pertenecían al complejo ST‐32/ET‐5. Los casos ST‐259 mostraban una tendencia hacia un mayor riesgo de desenlace fatal Los aislados ST‐259 no se detectaron entre controles geográficos o en otros estudios en Brasil. Conclusiones: Nuestros datos sugieren que los clones ST‐33 y ST‐259 y el surgimiento de los aislados ST‐103 contribuyen a la alta incidencia continua de la enfermedad meningocócica en Rio Grande do Sul. Objective To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Methods Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State. Results The overall incidence fell by 50%; the case‐fatality rate during this period was 22%. Even so, the incidence of MD remained high after the epidemic period ended in 1999. Together, the age groups of 1–4 years and infants accounted for 54.1% of reported cases with incidences of 11.3/100 000 and 31.3/100 000, respectively; 69.8% of cases were caused by Neisseria meningitidis serogroup B, which increased significantly. There was a significant decrease in serogroup C cases in the whole period. The phenotypes B:4,7:P1.19,15, B:15:P1.7,16 and B:NT:P1.3 caused almost 50% of all serotyped cases. Fifty‐six isolates obtained from RS patients during the first non‐epidemic year 2000 plus 20 isolates from other southern Brazilian states (Santa Catarina and Paraná), Denmark and France were typed by multilocus sequence typing. Twenty sequence types (STs) were identified, eight of them found only in RS. ST‐33 (27%) and ST‐259 (18%) were the most frequent; both belong to the ST‐32/ET‐5 complex. ST‐259 cases showed a trend towards higher risk of fatal outcome. ST‐259 isolates were not detected among geographic controls or in other studies in Brazil. Conclusion Our data suggest that ST‐33 and ST‐259 clones and the emergence of the ST‐103 isolates contributed to the continued high incidence of MD in RS. Épidémiologie de la maladie méningococcique dans le sud du Brésil de 1995 à 2003 et caractérisation moléculaire de Neisseria meningitidis en utilisant le typage de la séquence de multilocus Objectif: Décrire l’épidémiologie de la maladie méningococcique dans le sud du Brésil. Méthode: Etude de cohorte rétrospective sur 2215 cas de maladie méningococcique (MM) rapportés entre 1995 et 2003 dans l’état de Rio Grande do Sul (RS) au Brésil. Résultats: L’incidence globale a chuté de 50%. Le taux de cas fatals au cours de cette période était de 22%. Néanmoins, l’incidence de MM est demeurée élevée après la période épidémique finie en 1999. Au total, les groupes d’âge de 1 à 4 ans et les enfants en bas âge constituaient 54,1% des cas rapportés avec des incidences de 11,3/100000 et de 31,3/100000, respectivement. 69,8% des cas étaient causés par le sérogroupe B de Neisseria meningitidis , qui a augmenté de manière significative. Il y avait une diminution significative des cas dus au sérogroupe C dans toute la période. Les phénotypes B:4,7: P1.19,15, B:15:P1.7,16 et B:NT:P1.3 étaient responsables presque 50% de tous les cas sérotypés. 56 isolats obtenus à partir de patients de RS pendant la première année (2000) non épidémique et 20 isolats provenant d’autres états du sud du Brésil (Santa Catarina et Paraná), du Danemark et de France ont été typés par la typage de la séquence de multilocus. Vingt STs ont été identifiés, 8 d’entre eux ont été trouvés seulement à Rio Grande do Sul. ST‐33 (27%) et ST‐259 (18%) étaient les plus fréquents; tous les deux appartiennent au complexe ST‐32/ET‐5. Les cas ST‐259 indiquaientt une tendance vers un risque plus élevé de résultat mortel. Les isolats ST‐259 n’ont pas été détectés chez des contrôles géographiques ni dans d’autres études au Brésil. Conclusions: Nos données suggèrent que les clones ST‐33 et ST‐259 et l’émergence des isolats ST‐103 ont contribuéà l’incidence élevée continue de la maladie méningococcique à Rio Grande do Sul. Epidemiología de la Enfermedad Meningocócica al Sur de Brasil entre 1995 y 2003, y caracterización molecular Neisseria meningitidis mediante tipificación de la secuencia multilocus. Objetivo: Describir la epidemiología de la enfermedad meningocócica (EM) en el sur de Brasil. Método: Estudio de cohortes, entre 2,215 casos de enfermedad meningocócica reportados entre 1995 y 2003 en el estado de Rio Grande do Sul (RS), Brasil. Resultados: La incidencia total cayó en un 50%; la tasa de letalidad durante este periodo fue del 22%. Aún así, la incidencia de la EM se mantuvo alta después de que terminó el periodo epidémico en 1999. Los niños dentro del grupo de edad de 1–4 años y los bebes eran responsables del 54.1% de los casos reportados, con incidencias de 11.3/100000 y 31.3/100000, respectivamente. Un 69.8% de los casos era causado por Neisseria meningitidis serogrupo B, que aumentó significativamente. Hubo una disminución significativa en los casos de serogrupo C durante todo el periodo. Los fenotipos B:4,7:P1.19,15, B:15:P1.7,16 y B:NT:P1.3 causaron casi el 50% de todos los casos serotipados. 56 aislados obtenidos de pacientes de RS durante el 2000, primer año no epidémico, más 20 aislados de otros estados Brasileros (Santa Catarina y Paraná), Dinamarca y Francia fueron analizados mediante la Tipificación de la Secuencia Multilocus (ST). Se identificaron 20 STs, 8 de los cuales se encontraban solo en Rio Grande do Sul. ST‐33 (27%) y ST‐259 (18%) eran los más frecuentes; ambos pertenecían al complejo ST‐32/ET‐5. Los casos ST‐259 mostraban una tendencia hacia un mayor riesgo de desenlace fatal Los aislados ST‐259 no se detectaron entre controles geográficos o en otros estudios en Brasil. Conclusiones: Nuestros datos sugieren que los clones ST‐33 y ST‐259 y el surgimiento de los aislados ST‐103 contribuyen a la alta incidencia continua de la enfermedad meningocócica en Rio Grande do Sul. To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State. The overall incidence fell by 50%; the case-fatality rate during this period was 22%. Even so, the incidence of MD remained high after the epidemic period ended in 1999. Together, the age groups of 1-4 years and infants accounted for 54.1% of reported cases with incidences of 11.3/100 000 and 31.3/100 000, respectively; 69.8% of cases were caused by Neisseria meningitidis serogroup B, which increased significantly. There was a significant decrease in serogroup C cases in the whole period. The phenotypes B:4,7:P1.19,15, B:15:P1.7,16 and B:NT:P1.3 caused almost 50% of all serotyped cases. Fifty-six isolates obtained from RS patients during the first non-epidemic year 2000 plus 20 isolates from other southern Brazilian states (Santa Catarina and Paraná), Denmark and France were typed by multilocus sequence typing. Twenty sequence types (STs) were identified, eight of them found only in RS. ST-33 (27%) and ST-259 (18%) were the most frequent; both belong to the ST-32/ET-5 complex. ST-259 cases showed a trend towards higher risk of fatal outcome. ST-259 isolates were not detected among geographic controls or in other studies in Brazil. Our data suggest that ST-33 and ST-259 clones and the emergence of the ST-103 isolates contributed to the continued high incidence of MD in RS. SummaryObjectiveTo describe the epidemiology of meningococcal disease (MD) in southern Brazil.MethodsRetrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State.ResultsThe overall incidence fell by 50%; the case-fatality rate during this period was 22%. Even so, the incidence of MD remained high after the epidemic period ended in 1999. Together, the age groups of 1-4years and infants accounted for 54.1% of reported cases with incidences of 11.3/100000 and 31.3/100000, respectively; 69.8% of cases were caused by Neisseria meningitidis serogroup B, which increased significantly. There was a significant decrease in serogroup C cases in the whole period. The phenotypes B:4,7:P1.19,15, B:15:P1.7,16 and B:NT:P1.3 caused almost 50% of all serotyped cases. Fifty-six isolates obtained from RS patients during the first non-epidemic year 2000 plus 20 isolates from other southern Brazilian states (Santa Catarina and Parana), Denmark and France were typed by multilocus sequence typing. Twenty sequence types (STs) were identified, eight of them found only in RS. ST-33 (27%) and ST-259 (18%) were the most frequent; both belong to the ST-32/ET-5 complex. ST-259 cases showed a trend towards higher risk of fatal outcome. ST-259 isolates were not detected among geographic controls or in other studies in Brazil.ConclusionOur data suggest that ST-33 and ST-259 clones and the emergence of the ST-103 isolates contributed to the continued high incidence of MD in RS. Epidemiologie de la maladie meningococcique dans le sud du Bresil de 1995 a 2003 et caracterisation moleculaire de Neisseria meningitidis en utilisant le typage de la sequence de multilocusObjectif:Decrire l'epidemiologie de la maladie meningococcique dans le sud du Bresil.Methode:Etude de cohorte retrospective sur 2215 cas de maladie meningococcique (MM) rapportes entre 1995 et 2003 dans l'etat de Rio Grande do Sul (RS) au Bresil.Resultats:L'incidence globale a chute de 50%. Le taux de cas fatals au cours de cette periode etait de 22%. Neanmoins, l'incidence de MM est demeuree elevee apres la periode epidemique finie en 1999. Au total, les groupes d'age de 1 a 4 ans et les enfants en bas age constituaient 54,1% des cas rapportes avec des incidences de 11,3/100000 et de 31,3/100000, respectivement. 69,8% des cas etaient causes par le serogroupe B de Neisseria meningitidis, qui a augmente de maniere significative. Il y avait une diminution significative des cas dus au serogroupe C dans toute la periode. Les phenotypes B:4,7: P1.19,15, B:15:P1.7,16 et B:NT:P1.3 etaient responsables presque 50% de tous les cas serotypes. 56 isolats obtenus a partir de patients de RS pendant la premiere annee (2000) non epidemique et 20 isolats provenant d'autres etats du sud du Bresil (Santa Catarina et Parana), du Danemark et de France ont ete types par la typage de la sequence de multilocus. Vingt STs ont ete identifies, 8 d'entre eux ont ete trouves seulement a Rio Grande do Sul. ST-33 (27%) et ST-259 (18%) etaient les plus frequents; tous les deux appartiennent au complexe ST-32/ET-5. Les cas ST-259 indiquaientt une tendance vers un risque plus eleve de resultat mortel. Les isolats ST-259 n'ont pas ete detectes chez des controles geographiques ni dans d'autres etudes au Bresil.Conclusions:Nos donnees suggerent que les clones ST-33 et ST-259 et l'emergence des isolats ST-103 ont contribue a l'incidence elevee continue de la maladie meningococcique a Rio Grande do Sul. Epidemiologia de la Enfermedad Meningococica al Sur de Brasil entre 1995 y 2003, y caracterizacion molecular Neisseria meningitidis mediante tipificacion de la secuencia multilocus.Objetivo:Describir la epidemiologia de la enfermedad meningococica (EM) en el sur de Brasil.Metodo:Estudio de cohortes, entre 2,215 casos de enfermedad meningococica reportados entre 1995 y 2003 en el estado de Rio Grande do Sul (RS), Brasil.Resultados:La incidencia total cayo en un 50%; la tasa de letalidad durante este periodo fue del 22%. Aun asi, la incidencia de la EM se mantuvo alta despues de que termino el periodo epidemico en 1999. Los ninos dentro del grupo de edad de 1-4 anos y los bebes eran responsables del 54.1% de los casos reportados, con incidencias de 11.3/100000 y 31.3/100000, respectivamente. Un 69.8% de los casos era causado por Neisseria meningitidis serogrupo B, que aumento significativamente. Hubo una disminucion significativa en los casos de serogrupo C durante todo el periodo. Los fenotipos B:4,7:P1.19,15, B:15:P1.7,16 y B:NT:P1.3 causaron casi el 50% de todos los casos serotipados. 56 aislados obtenidos de pacientes de RS durante el 2000, primer ano no epidemico, mas 20 aislados de otros estados Brasileros (Santa Catarina y Parana), Dinamarca y Francia fueron analizados mediante la Tipificacion de la Secuencia Multilocus (ST).Se identificaron 20 STs, 8 de los cuales se encontraban solo en Rio Grande do Sul. ST-33 (27%) y ST-259 (18%) eran los mas frecuentes; ambos pertenecian al complejo ST-32/ET-5. Los casos ST-259 mostraban una tendencia hacia un mayor riesgo de desenlace fatal Los aislados ST-259 no se detectaron entre controles geograficos o en otros estudios en Brasil.Conclusiones:Nuestros datos sugieren que los clones ST-33 y ST-259 y el surgimiento de los aislados ST-103 contribuyen a la alta incidencia continua de la enfermedad meningococica en Rio Grande do Sul. Objective To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Methods Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State. Results The overall incidence fell by 50%; the case-fatality rate during this period was 22%. Even so, the incidence of MD remained high after the epidemic period ended in 1999. Together, the age groups of 1-4 years and infants accounted for 54.1% of reported cases with incidences of 11.3/100 000 and 31.3/100 000, respectively; 69.8% of cases were caused by Neisseria meningitidis serogroup B, which increased significantly. There was a significant decrease in serogroup C cases in the whole period. The phenotypes B:4,7:P1.19,15, B:15:P1.7,16 and B:NT:P1.3 caused almost 50% of all serotyped cases. Fifty-six isolates obtained from RS patients during the first non-epidemic year 2000 plus 20 isolates from other southern Brazilian states (Santa Catarina and Parana), Denmark and France were typed by multilocus sequence typing. Twenty sequence types (STs) were identified, eight of them found only in RS. ST-33 (27%) and ST-259 (18%) were the most frequent; both belong to the ST-32/ET-5 complex. ST-259 cases showed a trend towards higher risk of fatal outcome. ST-259 isolates were not detected among geographic controls or in other studies in Brazil. Conclusion Our data suggest that ST-33 and ST-259 clones and the emergence of the ST-103 isolates contributed to the continued high incidence of MD in RS. [PUBLICATION ABSTRACT] To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio Grande do Sul (RS) State. The overall incidence fell by 50%; the case-fatality rate during this period was 22%. Even so, the incidence of MD remained high after the epidemic period ended in 1999. Together, the age groups of 1-4 years and infants accounted for 54.1% of reported cases with incidences of 11.3/100 000 and 31.3/100 000, respectively; 69.8% of cases were caused by Neisseria meningitidis serogroup B, which increased significantly. There was a significant decrease in serogroup C cases in the whole period. The phenotypes B:4,7:P1.19,15, B:15:P1.7,16 and B:NT:P1.3 caused almost 50% of all serotyped cases. Fifty-six isolates obtained from RS patients during the first non-epidemic year 2000 plus 20 isolates from other southern Brazilian states (Santa Catarina and Paraná), Denmark and France were typed by multilocus sequence typing. Twenty sequence types (STs) were identified, eight of them found only in RS. ST-33 (27%) and ST-259 (18%) were the most frequent; both belong to the ST-32/ET-5 complex. ST-259 cases showed a trend towards higher risk of fatal outcome. ST-259 isolates were not detected among geographic controls or in other studies in Brazil. Our data suggest that ST-33 and ST-259 clones and the emergence of the ST-103 isolates contributed to the continued high incidence of MD in RS. |
| Author | Rossetti, M.L.R Abreu, M.F Kmetzsch, C Weidlich, L Klein, C Lemos, A.P Zaha, A Moraes, C Rios, S.S Riley, L.W Cafrune, P.I Nunes, L.S Sperb, A.F Baethgen, L.F |
| Author_xml | – sequence: 1 fullname: Baethgen, L.F – sequence: 2 fullname: Weidlich, L – sequence: 3 fullname: Moraes, C – sequence: 4 fullname: Klein, C – sequence: 5 fullname: Nunes, L.S – sequence: 6 fullname: Cafrune, P.I – sequence: 7 fullname: Lemos, A.P – sequence: 8 fullname: Rios, S.S – sequence: 9 fullname: Abreu, M.F – sequence: 10 fullname: Kmetzsch, C – sequence: 11 fullname: Sperb, A.F – sequence: 12 fullname: Riley, L.W – sequence: 13 fullname: Rossetti, M.L.R – sequence: 14 fullname: Zaha, A |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20168005$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18290999$$D View this record in MEDLINE/PubMed |
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| Snippet | To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio... Summary Objective To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Methods Retrospective cohort study among 2215 MD cases... To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Retrospective cohort study among 2215 MD cases reported from 1995 to 2003 in Rio... Objective To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Methods Retrospective cohort study among 2215 MD cases reported from... Objective To describe the epidemiology of meningococcal disease (MD) in southern Brazil. Methods Retrospective cohort study among 2215 MD cases reported from... SummaryObjectiveTo describe the epidemiology of meningococcal disease (MD) in southern Brazil.MethodsRetrospective cohort study among 2215 MD cases reported... OBJECTIVETo describe the epidemiology of meningococcal disease (MD) in southern Brazil.METHODSRetrospective cohort study among 2215 MD cases reported from 1995... |
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| SubjectTerms | Bacteremia - epidemiology Bacteremia - microbiology Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Typing Techniques Biological and medical sciences Brasil Brazil Brazil - epidemiology Brésil caracterización molecular caractérisation moléculaire Child, Preschool Cloning Epidemiology epidemiología Female General aspects Genotype & phenotype Human bacterial diseases Humans Incidence Infant Infant, Newborn Infectious diseases Male Medical sciences Meningitis Meningitis, Meningococcal - epidemiology Meningitis, Meningococcal - microbiology Meningococcal Infections - epidemiology Meningococcal Infections - microbiology molecular characterization Molecular Epidemiology Neisseria meningitidis Neisseria meningitidis - classification Neisseria meningitidis - genetics Neisseria meningitidis - isolation & purification Prevalence Rio Grande do Sul Seasons Sequence Analysis, DNA Serotyping épidémiologie |
| Title | Epidemiology of meningococcal disease in southern Brazil from 1995 to 2003, and molecular characterization of Neisseria meningitidis using multilocus sequence typing |
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