Effect of Cavity Disinfectants on Dentin Bond Strength and Clinical Success of Composite Restorations-A Systematic Review of In Vitro, In Situ and Clinical Studies
Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with antimicrobial agents before the use of adhesive systems. The aim of this study was to conduct a systematic review on the effect of different cavity di...
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Published in: | International journal of molecular sciences Vol. 22; no. 1; p. 353 |
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Abstract | Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with antimicrobial agents before the use of adhesive systems. The aim of this study was to conduct a systematic review on the effect of different cavity disinfectants on restorations' adhesion and clinical success. A search was carried out through the Cochrane Library, PubMed, and Web of Science. In vitro and in situ studies reporting results on dentin bond strength tests, and clinical studies published until August 2020, in English, Spanish and Portuguese were included. The methodological quality assessment of the clinical studies was carried out using the Revised Cochrane risk-of-bias tool. Chlorhexidine could preserve adhesion to dentin. EDTA and ethanol had positive results that should be further confirmed. Given the significant lack of scientific evidence, the use of lasers, fluoridated agents, sodium hypochlorite, or other products as cavity disinfectants should be avoided. Chlorhexidine is a safe option for cavity disinfection with adequate preservation of adhesion to dentin. Moreover, future researches should be focused on the efficacy of these disinfectants against cariogenic bacteria and their best application methods. |
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AbstractList | Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with antimicrobial agents before the use of adhesive systems. The aim of this study was to conduct a systematic review on the effect of different cavity disinfectants on restorations’ adhesion and clinical success. A search was carried out through the Cochrane Library, PubMed, and Web of Science. In vitro and in situ studies reporting results on dentin bond strength tests, and clinical studies published until August 2020, in English, Spanish and Portuguese were included. The methodological quality assessment of the clinical studies was carried out using the Revised Cochrane risk-of-bias tool. Chlorhexidine could preserve adhesion to dentin. EDTA and ethanol had positive results that should be further confirmed. Given the significant lack of scientific evidence, the use of lasers, fluoridated agents, sodium hypochlorite, or other products as cavity disinfectants should be avoided. Chlorhexidine is a safe option for cavity disinfection with adequate preservation of adhesion to dentin. Moreover, future researches should be focused on the efficacy of these disinfectants against cariogenic bacteria and their best application methods. |
Author | Miguel Marto, Carlos Marques Ferreira, Manuel Rascão, Beatriz Paula, Anabela Spagnuolo, Gianrico Coelho, Ana Marcelino, Inês Saraiva, José Carrilho, Eunice Amaro, Inês |
AuthorAffiliation | 4 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Napoli, Italy; gspagnuo@unina.it 6 Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal 5 Institute of Dentistry, I. M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia 2 Area of Environment Genetics and Oncobiology (CIMAGO), Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal; m.mferreira@netcabo.pt 8 Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, 3004-548 Coimbra, Portugal 1 Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal; ines.amaros@hotmail.com (I.A.); beatriznmfrascao@gmail.com (B.R.); inescarvalhomarcelino@gmail.com (I.M.); anabelabppaula@sapo.pt (A.P.); ze-93@hotmail.com (J.S.); cmiguel.marto@uc.pt (C.M.M.); eunicecarrilho |
AuthorAffiliation_xml | – name: 8 Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, 3004-548 Coimbra, Portugal – name: 1 Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal; ines.amaros@hotmail.com (I.A.); beatriznmfrascao@gmail.com (B.R.); inescarvalhomarcelino@gmail.com (I.M.); anabelabppaula@sapo.pt (A.P.); ze-93@hotmail.com (J.S.); cmiguel.marto@uc.pt (C.M.M.); eunicecarrilho@gmail.com (E.C.) – name: 6 Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal – name: 3 Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal – name: 5 Institute of Dentistry, I. M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia – name: 7 Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3004-548 Coimbra, Portugal – name: 2 Area of Environment Genetics and Oncobiology (CIMAGO), Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal; m.mferreira@netcabo.pt – name: 4 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Napoli, Italy; gspagnuo@unina.it |
Author_xml | – sequence: 1 givenname: Ana orcidid: 0000-0002-2924-7926 surname: Coelho fullname: Coelho, Ana organization: Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal – sequence: 2 givenname: Inês surname: Amaro fullname: Amaro, Inês organization: Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal – sequence: 3 givenname: Beatriz surname: Rascão fullname: Rascão, Beatriz organization: Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal – sequence: 4 givenname: Inês surname: Marcelino fullname: Marcelino, Inês organization: Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal – sequence: 5 givenname: Anabela orcidid: 0000-0001-6154-4173 surname: Paula fullname: Paula, Anabela organization: Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal – sequence: 6 givenname: José surname: Saraiva fullname: Saraiva, José organization: Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal – sequence: 7 givenname: Gianrico orcidid: 0000-0003-3769-9786 surname: Spagnuolo fullname: Spagnuolo, Gianrico organization: Institute of Dentistry, I. M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia – sequence: 8 givenname: Manuel orcidid: 0000-0002-5968-6161 surname: Marques Ferreira fullname: Marques Ferreira, Manuel organization: Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal – sequence: 9 givenname: Carlos orcidid: 0000-0001-9269-5417 surname: Miguel Marto fullname: Miguel Marto, Carlos organization: Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, 3004-548 Coimbra, Portugal – sequence: 10 givenname: Eunice orcidid: 0000-0002-5759-5557 surname: Carrilho fullname: Carrilho, Eunice organization: Clinical Academic Center of Coimbra (CACC), 3004-561 Coimbra, Portugal |
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Keywords | dental caries cavity disinfection adhesion chlorhexidine antimicrobial substances bonding |
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Snippet | Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with... |
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SubjectTerms | Adhesion Adhesives Anti-Infective Agents, Local - pharmacology Antiinfectives and antibacterials Antimicrobial agents antimicrobial substances Antiseptics Bond strength bonding cavity disinfection Chlorhexidine Composite Resins - chemistry Dental Bonding - methods Dental caries Dental restorative materials Dentin Dentin - drug effects Dentin-Bonding Agents - chemistry Disinfectants Disinfectants - pharmacology Disinfection Disinfection & disinfectants Disinfection - methods Ethanol Ethylenediaminetetraacetic acids Humans Lasers Materials Testing Pathology Quality assessment Quality control Rehabilitation Review Sodium Sodium hypochlorite Success Systematic review Teeth |
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Title | Effect of Cavity Disinfectants on Dentin Bond Strength and Clinical Success of Composite Restorations-A Systematic Review of In Vitro, In Situ and Clinical Studies |
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