Low-Molecular-Weight Heparin Reduces Ventilation-Induced Lung Injury through Hypoxia Inducible Factor-1α in a Murine Endotoxemia Model

Patients with sepsis frequently require mechanical ventilation (MV) to survive. However, MV has been shown to induce the production of proinflammatory cytokines, causing ventilator-induced lung injury (VILI). It has been demonstrated that hypoxia-inducible factor (HIF)-1α plays a crucial role in ind...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 21; no. 9; p. 3097
Main Authors:	Li, Li-Fu, Liu, Yung-Yang, Lin, Shih-Wei, Chang, Chih-Hao, Chen, Ning-Hung, Hung, Chen-Yiu, Lee, Chung-Shu
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 28-04-2020 MDPI
Subjects:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anticoagulants Apoptosis Chemokine CXCL2 - metabolism Cytokines Disease Models, Animal Edema Endotoxemia Endotoxemia - chemically induced Endotoxemia - genetics Endotoxemia - metabolism Endotoxemia - rehabilitation Endotoxins Enoxaparin - administration & dosage Enoxaparin - pharmacology Free radicals Gene expression Gene Expression Regulation - drug effects Growth factors Heparin Hypoxia hypoxia-inducible factor Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Inflammation Injections, Subcutaneous Injuries Injury prevention Interleukin 6 Interleukin-6 - metabolism Lipopolysaccharides - adverse effects low-molecular-weight heparin Lungs Macrophage inflammatory protein Male Metastases Mice Microvasculature mRNA Multiple organ dysfunction syndrome Neutrophils Oxidative stress Oxidative Stress - drug effects Permeability Proteins Respiration, Artificial - adverse effects Respiratory function Salmonella typhi - metabolism Salmonella typhi - pathogenicity Sepsis Transcription factors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism ventilator-induced lung injury Ventilator-Induced Lung Injury - drug therapy Ventilator-Induced Lung Injury - etiology Ventilator-Induced Lung Injury - genetics Ventilator-Induced Lung Injury - metabolism Ventilators Weight reduction hypoxia-inducible factor low-molecular-weight heparin ventilator-induced lung injury endotoxemia
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