Synthesis and Spectrum of Biological Activities of Novel N-arylcinnamamides

A series of sixteen ring-substituted -arylcinnamamides was prepared and characterized. Primary in vitro screening of all the synthesized compounds was performed against , three methicillin-resistant strains, H37Ra, , and . Several of the tested compounds showed antistaphylococcal, antitubercular, an...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 19; no. 8; p. 2318
Main Authors:	Pospisilova, Sarka, Kos, Jiri, Michnova, Hana, Kapustikova, Iva, Strharsky, Tomas, Oravec, Michal, Moricz, Agnes M, Bakonyi, Jozsef, Kauerova, Tereza, Kollar, Peter, Cizek, Alois, Jampilek, Josef
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 07-08-2018 MDPI
Subjects:	Ampicillin Antibiotics Antifungal activity antistaphylococcal activity antitubercular activity Benomyl Biocompatibility biofilm Biofilms Chloroplasts cinnamamides Ciprofloxacin Cytotoxicity Drug resistance Electron transport Fungicides Isoniazid Metabolism Methicillin Minimum inhibitory concentration MTT assay PET inhibition Photosynthesis Spinach Staphylococcus aureus structure–activity relationship time-kill assay toxicity Tuberculosis Vancomycin cinnamamides toxicity time-kill assay antistaphylococcal activity biofilm structure–activity relationship antitubercular activity PET inhibition MTT assay antifungal activity
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