Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 159; pp. 259 - 267
• Main Authors: Noro, Jennifer, Loureiro, Ana, Gonçalves, Filipa, Azoia, Nuno G., Jung, Seunho, Silva, Carla, Cavaco-Paulo, Artur
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-11-2017; Elsevier
• Subjects: Cyclo-oligosaccharides; Cyclosophoraose; Nanoemulsions; Palmitoyl chloride; Phase-change; Science & Technology; Ultrasound; Palmitoyl chloride; Nanoemulsions; Cyclo-oligosaccharides; Cyclosophoraose; Ultrasound; Phase-change
• ISSN: 0927-7765; 1873-4367; 0927-7765
• DOI: 10.1016/j.colsurfb.2017.07.055

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•New cyclo-oligosaccharide-palmitoyl compounds with improved emulsifying properties.•Cys-PAL-based nanoemulsions production via ultrasound-assisted methodology.•Narrow sized, monodisperse and nontoxic nanoemulsions for drugs encapsulation.
New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (∼50°C) and when submitted to ultrasound (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes.