Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia

• Published in: Turkish journal of obstetrics and gynecology Vol. 16; no. 2; pp. 91 - 94
• Main Authors: Anık İlhan, Gökçe, Yıldızhan, Begüm
• Format: Journal Article
• Language: English
• Published: Turkey Türk Jinekoloji ve Obstetrik Derneği 01-06-2019; Galenos Publishing House; Galenos Publishing
• Subjects: Angiogenesis; Apoptosis; Cancer; Cardiovascular disease; Clinical Investigation; Enzymes; Gynecology; Hypertension; Kadın Hastalıkları; Mortality; Pathogenesis; Preeclampsia; Pregnancy; Studies; Task forces; Tıp; Uric acid; Womens health; Ankara; Türkiye; Cathepsin B; preeclampsia; cathepsin D; cathepsin L; kathepsin D; kathepsin L; preeklampsi; Kathepsin B
• ISSN: 2149-9322; 2149-9330
• DOI: 10.4274/tjod.galenos.2019.40460

The aim of the study was to assess serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia.
One hundred forty pregnant women were enrolled in the study, of which 100 subjects were preeclamptic and 40 were healthy controls. Serum concentrations of cathepsin B, D, and L were measured and compared between the preeclamptic and control groups.
Cathepsin B and D concentrations were significantly higher in the preeclamptic group compared with the control group. There was no statistically significant difference between the groups in terms of cathepsin L concentrations. Cathepsin B concentrations were significantly higher in women with preeclampsia with severe features compared with those with preeclampsia alone.
Women with late-onset preeclampsia have significantly higher serum cathepsin B and D concentrations than controls. Cathepsin B and D may be promising biomarkers in women with late-onset preeclampsia.