Caviar Extract and Its Constituent DHA Inhibits UVB-Irradiated Skin Aging by Inducing Adiponectin Production

• Published in: International journal of molecular sciences Vol. 21; no. 9; p. 3383
• Main Authors: Lee, Kyung-Eun, Nho, Youn-Hwa, Yun, Seok Kyun, Park, Sung-Min, Kang, Seunghyun, Yeo, Hyeonju
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11-05-2020; MDPI
• Subjects: 3T3-L1 Cells; adipocyte differentiation; Adipocytes; Adipocytes - cytology; Adipocytes - drug effects; Adipocytes - metabolism; Adiponectin; Adiponectin - metabolism; Aging; Aging (artificial); Animals; caviar extract; Cell Differentiation - drug effects; Cell Line; Dermis; DHA; Differentiation; Docosahexaenoic acid; Docosahexaenoic Acids - pharmacology; Eggs; Eggs - analysis; Fatty acids; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibroblasts - radiation effects; Fish Products; Foreskin - cytology; Foreskin - drug effects; Foreskin - radiation effects; Gene expression; Gene Expression - drug effects; Gene Expression - radiation effects; Humans; Interstitial collagenase; Lipids; Male; Matrix metalloproteinase; Matrix Metalloproteinase 1 - genetics; Matrix Metalloproteinase 1 - metabolism; Matrix metalloproteinases; Metalloproteinase; Mice; MMP; Phospholipids; Physiology; Protein expression; Proteins; Skin; skin aging; Skin Aging - drug effects; Skin Aging - radiation effects; Studies; Sturgeon; Transcription factors; Ultraviolet Rays; MMP; adiponectin; skin aging; DHA; caviar extract; adipocyte differentiation
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21093383

In this study, caviar (sturgeon eggs) was used to elucidate its roles in adiponectin production and skin anti-aging. Recently, caviar has been largely used not only as a nutritional food, but also in cosmetic products. In particular, it has been reported that docosahexaenoic acid (DHA), as one of the main phospholipid components of caviar extract, induces intracellular lipid accumulation and the expression of adiponectin in adipocytes. Although adipocytes are well known to be associated with the skin dermis by secreting various factors (e.g., adiponectin), the effects of caviar extract and DHA on the skin are not well studied. Here, we demonstrate the effects of caviar extract and DHA on adipocyte differentiation and adiponectin production, resulting in a preventive role in UV-irradiated skin aging. Caviar extract and DHA enhanced adipocyte differentiation and promoted the synthesis of transcription factors controlling adipocyte differentiation and adiponectin. In addition, the mRNA expression levels of matrix metalloproteinase-1 (MMP-1) were decreased in UVB-irradiated Hs68 fibroblasts that were cultured in conditioned medium from caviar extract or DHA-treated differentiated adipocytes. Taken together, these results indicate that caviar extract and DHA induce adipocyte differentiation and adiponectin production, thereby inhibiting UVB-induced premature skin aging via the suppression of MMP-1 production.